Liu Kai, Ji Bai, Zhang Wei, Liu Songyang, Wang Yingchao, Liu Yahui
Department of Hepatobiliary and Pancreatic Surgery, the First Bethune Hospital, Jilin University, Jilin 130021, China.
Int J Med Sci. 2014 Jun 20;11(9):893-6. doi: 10.7150/ijms.8948. eCollection 2014.
This retrospective study compared the advantages and disadvantages of iodine-125 (125I) seed implantation and pancreaticoduodenectomy (PD) in the treatment of pancreatic cancer.
Patients with diagnosed pancreatic cancer who were treated with 125125I seed implantation (30 patients) or PD (30 patients) in our hospital were evaluated for operative time, bleeding, liver function, time to first bowel movement and normal diet, survival, and medical costs.
Compared with patients who underwent PD, those given 125I seed implantation had significantly shorter operative time, less bleeding, higher albumin, shorter periods to bowel movement and normal diet, lower risk of complications, and lower medical costs (P < 0.001, each). The difference of bilirubin level, time to feeding, and median survival were not significant statistically between two treatment grouops.
For pancreatic cancer patients for whom PD is not appropriate or who refuse PD, 125I seed implantation is a good option.
本回顾性研究比较了碘-125（¹²⁵I）粒子植入术与胰十二指肠切除术（PD）治疗胰腺癌的优缺点。
对我院确诊为胰腺癌并接受¹²⁵I粒子植入术（30例患者）或PD（30例患者）治疗的患者，评估其手术时间、出血量、肝功能、首次排便和正常饮食时间、生存率及医疗费用。
与接受PD的患者相比，接受¹²⁵I粒子植入术的患者手术时间明显更短、出血量更少、白蛋白水平更高、排便和恢复正常饮食的时间更短、并发症风险更低且医疗费用更低（每项P<0.001）。两组治疗组之间胆红素水平、进食时间和中位生存期的差异无统计学意义。
对于不适合或拒绝接受PD的胰腺癌患者，¹²⁵I粒子植入术是一个不错的选择。
