Menezes Luis Fernando, Germino Gregory George
Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10 Room 8D46, 10 Center Drive, Bethesda, MD 20892.
Drug Discov Today Dis Mech. 2013 Dec 1;10(3-4):e153-e158. doi: 10.1016/j.ddmec.2013.10.002.
Polycystic diseases affect approximately 1/1000 and are important causes of kidney failure. No therapies presently are in clinical practice that can prevent disease progression. Multiple mouse models have been produced for the genetic forms of the disease that most commonly affect humans. In this report, we review recent progress in the field and describe some of the outstanding challenges.
多囊性疾病影响约千分之一的人群，是肾衰竭的重要病因。目前尚无临床实践中可用于预防疾病进展的疗法。针对最常影响人类的该疾病遗传形式，已构建了多种小鼠模型。在本报告中，我们回顾了该领域的最新进展并描述了一些突出的挑战。
