Dehghani M, Poorseidi B, Sattari H, Nikeghbalian S, Zahedi M J, Seyyed-Mirzaei S M, Shafiei M, Vahedian M, Malek-Hosseini S A
Organ Transplant Research Center, Afzalipoor Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Organ Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Organ Transplant Med. 2012;3(3):120-3.
End-stage liver diseases are common in Iran. The only therapeutic option for these patients is liver transplantation.
To present our 2-year experience of liver transplantations in Afzalipoor Hospital, Kerman, southeastern Iran.
From November 2009 to September 2011, 12 patients underwent orthotopic liver transplantation in our center. Their data including demographics, indications for transplantation, MELD scores, post-operative complications and their management were collected.
Patients (7 women and 5 men) aged between 14 and 55 years. Indications for the transplantation included HBV infection (n=5), cryptogenic cirrhosis (n=2), Wilson's disease, alcoholism (n=1), HCV infection (n=1), Budd-Chiari syndrome (n=1), and autoimmune hepatitis (n=1). MELD score of patients ranged from 16 to 30. All patients received tacrolimus, mycophenolate mofetile and corticosteroid, postoperatively. 2 patients died of pulmonary and intra-abdominal infections with resultant to multiple organ failure. Nonfunctioning of transplanted liver and ongoing bleeding resulted in death in another patients. 9 patients are well doing and have excellent liver functions.
We had relatively successful results in our experience of orthotopic liver transplantation. Vicinity of our center to Shiraz Transplant Center would be an important factor in this success.
终末期肝病在伊朗很常见。这些患者唯一的治疗选择是肝移植。
介绍我们在伊朗东南部克尔曼省阿夫扎利普尔医院进行肝移植的2年经验。
2009年11月至2011年9月，我们中心有12例患者接受了原位肝移植。收集了他们的数据，包括人口统计学资料、移植指征、终末期肝病模型（MELD）评分、术后并发症及其处理情况。
患者年龄在14至55岁之间（7名女性和5名男性）。移植指征包括乙肝病毒感染（n = 5）、隐源性肝硬化（n = 2）、威尔逊病、酒精性肝病（n = 1）、丙肝病毒感染（n = 1）、布加综合征（n = 1）和自身免疫性肝炎（n = 1）。患者的MELD评分在16至30之间。所有患者术后均接受了他克莫司、霉酚酸酯和皮质类固醇治疗。2例患者死于肺部和腹腔感染，导致多器官功能衰竭。另1例患者因移植肝无功能和持续出血死亡。9例患者情况良好，肝功能极佳。
我们原位肝移植的经验取得了相对成功的结果。我们中心靠近设拉子移植中心是取得这一成功的重要因素。
