Edwards J D, Grant P T, Plunkett P, Nightingale P
Intensive Care Unit, University Hospital of South Manchester, Withington, England.
Intensive Care Med. 1989;15(4):247-9. doi: 10.1007/BF00271060.
The use of sublingual nitroglycerin spray has been studied in twenty patients referred to our Intensive Care Unit for further treatment of severe left ventricular failure. Within five minutes of spray administration significant falls in pulmonary artery occlusion pressure, mean arterial pressure, heart rate, right atrial pressure and systemic vascular resistance occurred. Similarly significant increases in cardiac index, stroke volume index and left ventricular stroke work index were found. These results show a considerable improvement in the haemodynamic parameters of invasively monitored patients and we believe that its administration undoubtedly "buys time" for the critically ill patient. However, we would caution against its routine use at present in view of the potential problem of hypotension, until further information is available.
对20例因严重左心室衰竭转诊至我们重症监护病房接受进一步治疗的患者使用了舌下硝酸甘油喷雾剂进行研究。喷雾给药后五分钟内，肺动脉闭塞压、平均动脉压、心率、右心房压和全身血管阻力显著下降。同样，心脏指数、每搏量指数和左心室每搏功指数也显著增加。这些结果表明，接受有创监测的患者的血流动力学参数有了相当大的改善，我们认为其给药无疑为重症患者“赢得了时间”。然而，鉴于存在低血压的潜在问题，在获得更多信息之前，我们目前谨慎反对常规使用它。
