Gwilt D J, Petri M, Reid D S
Eur Heart J. 1983 Oct;4(10):712-7. doi: 10.1093/oxfordjournals.eurheartj.a061383.
The haemodynamic effects of intravenous isosorbide dinitrate (Cedocard) in patients with severe acute left ventricular failure have been assessed using incremental infusion rates from 50 to 800 micrograms min-1. For most patients most of the fall in pulmonary arterial diastolic pressure occurred by 200 micrograms min-1, with little further fall at higher doses. At 200 micrograms min-1 pulmonary arterial diastolic pressure fell from 29 to 23 mgHg (P less than 0.001), there was no significant change in cardiac index (1.9 to 2.0 L min-1 m-2) or heart rate (108 to 108 beats min-1). Despite high doses, no side effects were observed. Intravenous isosorbide dinitrate is effective and safe in the management of acute severe left ventricular failure. In most patients an infusion rate of about 200 micrograms min-1 produces optimal haemodynamic effects.
已采用50至800微克/分钟的递增输注速率，评估了静脉注射硝酸异山梨酯（Cedocard）对重症急性左心室衰竭患者的血流动力学影响。对于大多数患者而言，肺动脉舒张压的下降大多在200微克/分钟时出现，更高剂量时进一步下降幅度很小。在200微克/分钟时，肺动脉舒张压从29降至23 mmHg（P<0.001），心脏指数（1.9至2.0升/分钟/平方米）或心率（108至108次/分钟）无显著变化。尽管使用了高剂量，但未观察到副作用。静脉注射硝酸异山梨酯在急性重症左心室衰竭的治疗中有效且安全。在大多数患者中，约200微克/分钟的输注速率可产生最佳血流动力学效果。
