Warden Melissa R, Cardin Jessica A, Deisseroth Karl
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853; email:
Annu Rev Biomed Eng. 2014 Jul 11;16:103-29. doi: 10.1146/annurev-bioeng-071813-104733.
Genetically encoded optical actuators and indicators have changed the landscape of neuroscience, enabling targetable control and readout of specific components of intact neural circuits in behaving animals. Here, we review the development of optical neural interfaces, focusing on hardware designed for optical control of neural activity, integrated optical control and electrical readout, and optical readout of population and single-cell neural activity in freely moving mammals.
基因编码的光学致动器和指示剂改变了神经科学的面貌,能够在行为动物中对完整神经回路的特定组件进行靶向控制和读出。在这里,我们回顾光学神经接口的发展,重点关注用于神经活动光学控制、集成光学控制和电读出以及自由移动哺乳动物群体和单细胞神经活动光学读出的硬件。