色素性睫状体上皮腺癌
Adenocarcinoma of the pigmented ciliary epithelium.
作者信息
Sukeda Aoi, Mori Taisuke, Suzuki Shigenobu, Ochiai Atsushi
机构信息
Department of Pathology and Clinical Laboratories, National Cancer Center Central Hospital, Tokyo, Japan.
Department of Opthalamic Tumor, National Cancer Center Central Hospital, Tokyo, Japan.
出版信息
BMJ Case Rep. 2014 Jul 11;2014:bcr2014204534. doi: 10.1136/bcr-2014-204534.
Adenocarcinoma of the pigmented ciliary epithelium is an exceptionally rare eye tumour, with only a few cases reported to date. We encountered such a case in a 50-year-old woman who reported seeing floaters in her right eye. Fundus examination and MRI revealed an elevated lesion located in the ciliary body compressing the lens. The ciliary body was resected under the diagnosis of ciliary adenoma. On histological examination, the tumour exhibited epithelial features with glandular formation and moderate nuclear pleomorphism. The tumour invaded the subepithelial stroma of the ciliary body. Immunohistochemical findings were positive for cytokeratin OSCAR, AE1/AE3, CK7, EMA, S100, Melan A, HMB45, and microphthalmia-associated transcription factor.
色素性睫状体上皮腺癌是一种极为罕见的眼部肿瘤，迄今为止仅有少数病例报道。我们遇到了一名50岁女性患者，她自述右眼有飞蚊症。眼底检查和磁共振成像显示，睫状体有一个隆起病变，压迫晶状体。在诊断为睫状体腺瘤的情况下，切除了睫状体。组织学检查显示，肿瘤具有上皮特征，有腺管形成，核多形性中等。肿瘤侵犯了睫状体的上皮下基质。免疫组化结果显示，细胞角蛋白OSCAR、AE1/AE3、CK7、上皮膜抗原、S100、黑素A、HMB45和小眼相关转录因子呈阳性。
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