Miura K, Morisaki S, Abe S, Higashijima A, Hasegawa Y, Miura S, Tateishi S, Mishima H, Yoshiura K, Masuzaki H
Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Placenta. 2014 Oct;35(10):848-51. doi: 10.1016/j.placenta.2014.06.002. Epub 2014 Jun 26.
The aim of this study was to investigate the relationship between plasma concentration of cell-free pregnancy-associated placenta-specific microRNAs and clinical variables (placental weight, maternal body mass index, and neonatal birth weight). Circulating levels of cell-free pregnancy-associated placenta-specific microRNAs (miR-515-3p, miR-517a, miR-517c and miR-518b) in maternal plasma were measured by quantitative real-time RT-PCR in sixty-two pregnant women. The levels of cell-free pregnancy-associated placenta-specific microRNAs were significantly associated with placental weight, but not associated with body mass index or birth weight. Therefore, the measurement of cell-free pregnancy-associated placenta-specific miRNAs levels in maternal plasma may reflect the pregnancy status related to placenta volume.
本研究的目的是探讨游离妊娠相关胎盘特异性微小RNA的血浆浓度与临床变量（胎盘重量、母体体重指数和新生儿出生体重）之间的关系。通过定量实时逆转录聚合酶链反应检测了62名孕妇母体血浆中游离妊娠相关胎盘特异性微小RNA（miR-515-3p、miR-517a、miR-517c和miR-518b）的循环水平。游离妊娠相关胎盘特异性微小RNA的水平与胎盘重量显著相关，但与体重指数或出生体重无关。因此，检测母体血浆中游离妊娠相关胎盘特异性微小RNA的水平可能反映与胎盘体积相关的妊娠状态。
