Kanis Luiz A, Marques Ellen L, Zepon Karine M, Pereira Jefferson R, Pamato Saulo, de Oliveira Marcelo T, Danielski Lucinéia G, Petronilho Fabricia C
TECFARMA, University of Southern Santa Catarina, Tubarão, SC, Brazil Post Graduated Program in Health Science, University of Southern Santa Catarina, Tubarão, SC, Brazil.
TECFARMA, University of Southern Santa Catarina, Tubarão, SC, Brazil.
J Biomater Appl. 2014 Nov;29(5):654-61. doi: 10.1177/0885328214542488. Epub 2014 Jul 10.
This study reports the results of the characterization of cellulose acetate butyrate and polycaprolactone-triol blends in terms of miscibility, swelling capacity, mechanical properties, and inflammatory response in vivo. The cellulose acetate butyrate film was opaque and rigid, with glass transition (T g ) at 134℃ and melting temperature of 156℃. The cellulose acetate butyrate/polycaprolactone-triol films were transparent up to a polycaprolactone-triol content of 60%. T g of the cellulose acetate butyrate films decreased monotonically as polycaprolactone-triol was added to the blend, thus indicating miscibility. FTIR spectroscopy revealed a decrease in intramolecular hydrogen bonding in polycaprolactone-triol, whereas no hydrogen bonding was observed between cellulose acetate butyrate and -OH from polycaprolactone-triol. The increase in polycaprolactone-triol content in the blend decreased the water uptake. An increase in polycaprolactone-triol content decreased the modulus of elasticity and increased the elongation at break. A cellulose acetate butyrate/polycaprolactone-triol 70/30 blend implanted in rats showed only an acute inflammatory response 7 days after surgery. No change in inflammation mediators was observed.
本研究报告了醋酸丁酸纤维素与聚己内酯三醇共混物在混溶性、溶胀能力、机械性能及体内炎症反应方面的表征结果。醋酸丁酸纤维素薄膜不透明且坚硬，玻璃化转变温度（Tg）为134℃，熔点为156℃。醋酸丁酸纤维素/聚己内酯三醇薄膜在聚己内酯三醇含量达60%时仍保持透明。随着聚己内酯三醇添加到共混物中，醋酸丁酸纤维素薄膜的Tg单调下降，表明两者可混溶。傅里叶变换红外光谱显示聚己内酯三醇分子内氢键减少，而醋酸丁酸纤维素与聚己内酯三醇的 -OH之间未观察到氢键。共混物中聚己内酯三醇含量增加，吸水率降低。聚己内酯三醇含量增加，弹性模量降低，断裂伸长率增加。植入大鼠体内的醋酸丁酸纤维素/聚己内酯三醇70/30共混物在术后7天仅表现出急性炎症反应。未观察到炎症介质的变化。
