表面活性剂组成对包封ω-3鱼油的皂树皂苷稳定脂质颗粒的物理和氧化稳定性的影响。
Influence of surfactant composition on physical and oxidative stability of Quillaja saponin-stabilized lipid particles with encapsulated ω-3 fish oil.
作者信息
Salminen Hanna, Aulbach Susanne, Leuenberger Bruno H, Tedeschi Concetta, Weiss Jochen
机构信息
Department of Food Physics and Meat Science, Institute of Food Science and Biotechnology, University of Hohenheim, Garbenstrasse 21/25, 70599 Stuttgart, Germany.
Department of Food Physics and Meat Science, Institute of Food Science and Biotechnology, University of Hohenheim, Garbenstrasse 21/25, 70599 Stuttgart, Germany.
出版信息
Colloids Surf B Biointerfaces. 2014 Oct 1;122:46-55. doi: 10.1016/j.colsurfb.2014.06.045. Epub 2014 Jun 28.
The purpose of this study was to investigate the potential of a saponin-rich extract of Quillaja saponaria to replace bile salts in the surfactant formulations for stabilization of nanostructured lipid carriers (NLC). The influence of Quillaja extract and/or high-melting lecithin at different concentrations on physical and oxidative stability was evaluated in (i) NLC containing tristearin and ω-3 fish oil, (ii) ω-3 fish oil-in-water emulsion, and (iii) solid lipid nanoparticles (SLN) containing tristearin. Best physical, polymorphic and oxidative stability of NLC were achieved with a surfactant combination of 2.4% (w/w) Quillaja extract and 0.6% (w/w) high-melting lecithin. The results showed that encapsulation of ω-3 fish oil into NLC inhibited the formation of lipid hydroperoxides, propanal and hexanal by 72, 53 and 57%, respectively, compared to the fish oil-in-water emulsion prepared with the same surfactants. This indicated that the low oxidation observed in NLC cannot be due to potential antioxidative effects of the surfactant combination itself. Evidence is accumulating that tristearin is able to form a protective shell around the ω-3 fish oil, when crystallization is induced via high-melting phospholipids in the solidified interfacial layer.
本研究的目的是探究皂树富含皂苷的提取物在纳米结构脂质载体（NLC）表面活性剂配方中替代胆盐以实现稳定化的潜力。在以下体系中评估了不同浓度的皂树提取物和/或高熔点卵磷脂对物理稳定性和氧化稳定性的影响：（i）含有三硬脂酸甘油酯和ω-3鱼油的NLC，（ii）水包油型ω-3鱼油乳液，以及（iii）含有三硬脂酸甘油酯的固体脂质纳米粒（SLN）。当使用2.4%（w/w）皂树提取物和0.6%（w/w）高熔点卵磷脂的表面活性剂组合时，NLC实现了最佳的物理、多晶型和氧化稳定性。结果表明，与使用相同表面活性剂制备的水包油型鱼油乳液相比，将ω-3鱼油包裹于NLC中分别使脂质氢过氧化物、丙醛和己醛的形成减少了72%、53%和57%。这表明在NLC中观察到的低氧化现象并非源于表面活性剂组合本身潜在的抗氧化作用。越来越多的证据表明，当通过固化界面层中的高熔点磷脂诱导结晶时，三硬脂酸甘油酯能够在ω-3鱼油周围形成一个保护壳。
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