Maurya Vaibhav Kumar, Shakya Amita, Aggarwal Manjeet, Gothandam Kodiveri Muthukaliannan, Bohn Torsten, Pareek Sunil
Department of Basic and Applied Science, National Institute of Food Technology Entrepreneurship and Management, Kundli, Sonepat 131 028, Haryana, India.
Department of Agriculture and Environmental Sciences, National Institute of Food Technology Entrepreneurship and Management, Kundli, Sonepat 131 028, Haryana, India.
Antioxidants (Basel). 2021 Mar 10;10(3):426. doi: 10.3390/antiox10030426.
Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers have some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has rapidly evolved, with a plethora of innovative nanoengineered materials now being in use, including micelles, nano/microemulsions, liposomes, niosomes, solidlipid nanoparticles, nanostructured lipids and nanostructured carriers. These nanodelivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nanodelivery systems adopted for developing functional foods, depicting their classifications, compositions, preparation methods, challenges, release and absorption of β-carotene in the gastrointestinal tract (GIT) and possible risks and future prospects.
纳米技术为生物活性物质的递送带来了新机遇。其物理化学特性,即尺寸小、比表面积大、组成独特、生物相容性和生物降解性,使这些纳米材料成为递送β-胡萝卜素的有吸引力的工具。通过纳米颗粒递送β-胡萝卜素不仅能提高其在靶组织中的生物利用度/生物蓄积性,还能降低其在加工过程中对环境因素的敏感性。尽管有这些益处,但纳米载体也存在一些局限性,如感官品质变化、食品基质改变、成本增加,以及消费者接受度有限和监管挑战。这一研究领域发展迅速,现在有大量创新的纳米工程材料正在使用,包括胶束、纳米/微乳液、脂质体、非离子表面活性剂泡囊、固体脂质纳米颗粒、纳米结构脂质和纳米结构载体。这些纳米递送系统使传统递送系统显得过时,并有望实现更好的增溶、加工过程中的保护、延长保质期、更高的生物利用度以及控释和靶向释放。本综述提供了有关用于开发功能性食品的β-胡萝卜素纳米递送系统的知识现状信息,描述了它们的分类、组成、制备方法、挑战、β-胡萝卜素在胃肠道(GIT)中的释放和吸收以及可能的风险和未来前景。