阿芬太尼和咪达唑仑：用于持续输注的新型麻醉药物及自动给药方法。

Alfentanil and midazolam: new anesthetic drugs for continuous infusion and an automated method of administration.

作者信息

Reves J G, Glass P, Jacobs J R

出版信息

Mt Sinai J Med. 1989 Mar;56(2):99-107.

Abstract

New drugs like alfentanil and midazolam have the primary advantage of metabolizing faster than existing compounds in their class. Because of shorter plasma half-lives, the drugs are well suited for continuous infusion. In our hands, CACI is a valuable clinical instrument and research tool. Although some anesthetic drugs can be given safely and effectively by bolus injection, whenever a titrated continuous infusion is appropriate (and physiologically closed-loop delivery is not possible), use of a CACI-type instrument should be the preferred method of administration. With the availability for continuous infusion of alfentanil and midazolam, with their highly desirable pharmacodynamic properties and relatively effervescent pharmacokinetics, we believe that computerized pharmacokinetic model-driven infusion devices will play a significant role in future anesthetic practice.

摘要

像阿芬太尼和咪达唑仑这样的新药，其主要优势在于代谢速度比同类现有化合物更快。由于血浆半衰期较短，这些药物非常适合持续输注。在我们的实践中，计算机辅助持续输注（CACI）是一种有价值的临床仪器和研究工具。虽然一些麻醉药物通过大剂量注射可以安全有效地给药，但只要适合进行滴定式持续输注（且无法进行生理闭环给药），使用CACI类仪器应是首选的给药方法。随着阿芬太尼和咪达唑仑可用于持续输注，它们具有非常理想的药效学特性和相对较快的药代动力学，我们相信计算机化药代动力学模型驱动的输注设备将在未来的麻醉实践中发挥重要作用。