Oset Piotr, Talar-Wojnarowska Renata, Kumor Anna, Małecka-Panas Ewa
Przegl Lek. 2014;71(2):78-81.
It has been shown that local chronic inflammation may lead to colorectal carcinogenesis via adenomatous polyps. Tumor necrosing factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP) are biomarkers of inflammation and indicators of the immune response to tumors. Their elevated levels were observed in patients with colon adenomas, however their clinical significance is unclear.
The study included sixty patients with the colorectal adenomatous polyps found on colonoscopy and confirmed pathologically. The control group consisted of 30 individuals with no positive findings on colonoscopy. The aim of our study was to determine the serum levels of TNF-alpha, IL-6 and CRP in colorectal adenomas patients and to assessed the relationships between them and colorectal adenoma location, dysplasia grading, histological type, and size.
One hundred nine adenomas (6-40 mm of size) were found in 60 study patients. The average age of patients with multiple polyps was significantly higher than of those with single pathologies (61.1 vs 56.7 years respectively (p < 0.05)). The prevalence of colon adenomas were observed in distal part of colon (83.3%), compared to the proximal part (16.7%; p < 0.01). The TNF-alpha concentration was similar in both group (24.51 +/- 13.50 pg/ml versus 29.61 +/- 14.94 pg/ml; p > 0.05) and not related to clinical data of patients. In contrast, CRP serum concentrations were higher in patients with adenomas located proximally (8.674 +/- 9.19 microg/ml) compared to control group (4.94 +/- 5.53 microg/ml; p < 0.05). There was also no differences between IL-6 serum level in patients with colon adenomas (19.80 +/- 7.44 pg/ml) and control group (20.46 +/-11.83 pg/ml; p > 0.05). Analyzed cytokines serum levels were not associated with size, number, degree of dysplasia and histological type of colon adenomas.
Our results indicate that CRP may be associated with development of tumors of proximal part of colon.
研究表明，局部慢性炎症可能通过腺瘤性息肉导致结直肠癌发生。肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和C反应蛋白（CRP）是炎症生物标志物及肿瘤免疫反应指标。在结肠腺瘤患者中观察到它们水平升高，但其临床意义尚不清楚。
本研究纳入60例经结肠镜检查发现并经病理证实的结直肠腺瘤性息肉患者。对照组由30例结肠镜检查无阳性发现的个体组成。我们研究的目的是测定结直肠腺瘤患者血清中TNF-α、IL-6和CRP水平，并评估它们与结直肠腺瘤位置、发育异常分级、组织学类型和大小之间的关系。
60例研究患者共发现109个腺瘤（大小为6 - 40毫米）。多发息肉患者的平均年龄显著高于单发息肉患者（分别为61.1岁和56.7岁，p < 0.05）。结肠腺瘤在结肠远端的患病率为83.3%，而近端为16.7%（p < 0.01）。两组TNF-α浓度相似（24.51±13.50 pg/ml对29.61±14.94 pg/ml；p > 0.05），且与患者临床资料无关。相比之下，近端有腺瘤患者的CRP血清浓度（8.674±9.19微克/毫升）高于对照组（4.94±5.53微克/毫升；p < 0.05）。结肠腺瘤患者的IL-6血清水平（19.80±7.44 pg/ml）与对照组（20.46±11.83 pg/ml；p > 0.05）也无差异。分析的细胞因子血清水平与结肠腺瘤的大小、数量、发育异常程度和组织学类型无关。
我们的结果表明，CRP可能与结肠近端肿瘤的发生有关。
