Szöllősi Attila G, Oláh Attila, Bíró Tamás, Tóth Balázs István
Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Dermatoendocrinol. 2018 Jan 23;9(1):e1361576. doi: 10.1080/19381980.2017.1361576. eCollection 2017.
The sebaceous gland, long considered an evolutionary relic with little-to-no physiological relevance in humans, has emerged in recent decades as a key orchestrator and contributor to many cutaneous functions. In addition to the classical physico-chemical barrier function of the skin against constant environmental challenges, a more novel, neuro-immune modulatory role has also emerged. As part of the complex intercellular communication network of the integumentary system, the sebaceous gland acts as a "relay station" in the skin for many endocrine factors. This review aims to offer a comprehensive overview of endocrine effects and subsequent interactions on this much maligned mini-organ.
皮脂腺长期以来被认为是一种进化遗迹，在人类生理过程中几乎没有相关性，但近几十年来，它已成为许多皮肤功能的关键协调者和贡献者。除了皮肤针对持续环境挑战的经典物理化学屏障功能外，一种更新颖的神经免疫调节作用也已显现。作为皮肤系统复杂细胞间通讯网络的一部分，皮脂腺在皮肤中充当许多内分泌因子的“中继站”。本综述旨在全面概述这种备受诋毁的小器官的内分泌效应及其后续相互作用。
