Goossens R An
Contact Allergy Unit, Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Leuven B-3000, Belgium.
Immunol Allergy Clin North Am. 2014 Aug;34(3):663-70, ix-x. doi: 10.1016/j.iac.2014.04.010.
The local application of pharmaceutical products may induce skin adverse reactions, including allergic contact dermatitis. Indeed, pharmaceutical products are, in general, applied on diseased or inflamed skin, the barrier function of which is often incapacitated, leading to enhanced skin penetration of the applied chemicals. Under these circumstances, even weak allergens are in such cases able to induce sensitization. The contact allergens in topical pharmaceutical products concern active principles and vehicle components, the latter of which are discussed in this article.
药品的局部应用可能会引发皮肤不良反应，包括过敏性接触性皮炎。实际上，药品通常是应用于患病或发炎的皮肤，而这类皮肤的屏障功能往往已丧失，从而导致所施用化学物质的皮肤渗透性增强。在这种情况下，即使是弱过敏原也能够引发致敏反应。局部用药品中的接触性过敏原涉及活性成分和赋形剂成分，本文将讨论后者。
