Biology Department, Abilene Christian University, Abilene, TX, USA.
Infect Drug Resist. 2014 Jun 20;7:167-76. doi: 10.2147/IDR.S48820. eCollection 2014.
Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic resistance among pathogens. This review aims to give an overview of the major horizontal transfer mechanisms and their evolution and then demonstrate the human lower gastrointestinal tract as an environment in which horizontal gene transfer of resistance determinants occurs. Finally, implications for antibiotic usage and the development of resistant infections and persistence of antibiotic resistance genes in populations as a result of horizontal gene transfer in the large intestine will be discussed.
由于病原体对抗生素的广泛耐药性，细菌感染的治疗变得越来越困难。本综述旨在概述主要的水平转移机制及其进化，然后展示人类下消化道作为抗性决定因素发生水平基因转移的环境。最后，将讨论由于大肠中的水平基因转移对抗生素使用、耐药感染的发展以及人群中抗生素耐药基因的持久性的影响。
