Liu Xue-Hua, Li Qing, Zhang Pei, Su Yi, Zhang Xue-Ru, Sun Qiang
Department of Intensive Care Unit, TianJin People's Hospital , TianJin, China .
Genet Test Mol Biomarkers. 2014 Sep;18(9):630-5. doi: 10.1089/gtmb.2014.0038. Epub 2014 Jul 14.
The aim of this study was to identify whether mannose-binding lectin (MBL) and C-reactive protein (CRP) may be used as clinical biomarkers for predicting outcome of community-acquired pneumonia (CAP) by tracking serum MBL and CRP level changes during a time course.
One hundred four patients with CAP and 100 healthy individuals were enrolled in this study. The patients were further divided into Survivor and Death groups based on 30-day mortality. The MBL and CRP levels in these patients at pre- and post-treatments at days 4 and 7 were determined using an immunoturbidimetric assay and an enzyme-linked immunosorbent assay (ELISA).
Compared to the control group, the MBL and CRP levels in the CAP group were significantly higher. CRP levels in the CAP group significantly reduced within 1 week following anti-infection and other supporting therapies including anti-phlegm and liquidation. MBL levels were significantly higher in the Survivor group than in the Death group (p<0.05). On the contrary, CRP levels were significantly higher in the Death group than in the Survivor group (p<0.05). There was a negative correlation between the serum MBL and CRP levels in all patients following the treatments.
Both the MBL and CRP can serve as inflammatory markers in predicting the outcome of patients with CAP.
本研究旨在通过追踪社区获得性肺炎（CAP）患者病程中血清甘露糖结合凝集素（MBL）和C反应蛋白（CRP）水平的变化，确定MBL和CRP是否可作为预测CAP患者预后的临床生物标志物。
本研究纳入了104例CAP患者和100例健康个体。根据30天死亡率将患者进一步分为存活组和死亡组。采用免疫比浊法和酶联免疫吸附测定（ELISA）法测定这些患者治疗前及治疗后第4天和第7天的MBL和CRP水平。
与对照组相比，CAP组的MBL和CRP水平显著更高。CAP组的CRP水平在抗感染及其他支持治疗（包括祛痰和补液）后1周内显著降低。存活组的MBL水平显著高于死亡组（p<0.05）。相反，死亡组的CRP水平显著高于存活组（p<0.05）。治疗后所有患者的血清MBL和CRP水平呈负相关。
MBL和CRP均可作为预测CAP患者预后的炎症标志物。
