CCR7：在癌细胞播散、迁移和转移形成中的作用。
CCR7: roles in cancer cell dissemination, migration and metastasis formation.
作者信息
Legler Daniel F, Uetz-von Allmen Edith, Hauser Mark A
机构信息
Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.
Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.
出版信息
Int J Biochem Cell Biol. 2014 Sep;54:78-82. doi: 10.1016/j.biocel.2014.07.002. Epub 2014 Jul 11.
The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.
C-C趋化因子受体7（CCR7）协调癌细胞以及免疫细胞向淋巴器官的迁移，其两种配体CCL19和CCL21在淋巴器官中组成性表达。在此，我们提供了CCR7的拓扑模型，CCR7属于A类G蛋白偶联的七跨膜受体，并描述了CCR7表达是如何被调控的。我们重点关注其在癌细胞迁移和转移形成中的作用，并讨论癌细胞如何利用CCR7或其配体来逃避免疫监视。
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