近红外触发可切换轮烷功能化二氧化硅包覆金纳米棒的药物释放。
NIR-triggered drug release from switchable rotaxane-functionalized silica-covered Au nanorods.
作者信息
Li Menghuan, Yan Hong, Teh Cathleen, Korzh Vladimir, Zhao Yanli
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
出版信息
Chem Commun (Camb). 2014 Sep 4;50(68):9745-8. doi: 10.1039/c4cc02966f.
PMID:25019373
Abstract
An NIR-triggered drug delivery system was developed by capping photo-switchable azobenzene-based rotaxane onto Au nanorod-mesoporous silica core-shell hybrids. Drug release from the nanocarrier in zebrafish embryo models could be controlled remotely under NIR irradiation, showing significant drug spreading to the adjacent tissues.
摘要
通过将基于光开关偶氮苯的轮烷包覆在金纳米棒-介孔二氧化硅核壳杂化材料上，开发了一种近红外触发的药物递送系统。在斑马鱼胚胎模型中，纳米载体的药物释放在近红外照射下可远程控制，显示出药物显著扩散到相邻组织。
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