Paryente Sapir, Aledwan Hajar, Saady Abed
Department of Chemistry, Bar-Ilan University, Ramat Gan, Israel.
Commun Chem. 2025 May 14;8(1):149. doi: 10.1038/s42004-025-01555-6.
Mechanically interlocked molecules (MIMs) such as rotaxanes and catenanes attract significant interest due to their unique structures and dynamic properties. Cyclodextrin-based rotaxanes (CD-rotaxanes) have emerged as promising supramolecular systems for biological and medicinal applications. Their host-guest interactions and mechanical bonds provide enhanced stability, stimuli-responsiveness, and tunable functionality. This review highlights their roles in targeted therapy, controlling drug release, theranostic agents, enzyme inhibitor, gene transport and bioimaging. Challenges and future perspectives in translating CD-rotaxanes to biomedical applications are discussed, emphasizing their potential as a next-generation therapeutic platform.
诸如轮烷和索烃之类的机械互锁分子（MIMs）因其独特的结构和动态特性而备受关注。基于环糊精的轮烷（CD-轮烷）已成为用于生物和医学应用的有前景的超分子体系。它们的主客体相互作用和机械键提供了增强的稳定性、刺激响应性和可调功能。本综述重点介绍了它们在靶向治疗、控制药物释放、诊疗试剂、酶抑制剂、基因转运和生物成像中的作用。讨论了将CD-轮烷转化为生物医学应用面临的挑战和未来前景，强调了它们作为下一代治疗平台的潜力。
