Su Qiang, Zhang Jian-Ming, Li Ming
Zhongguo Zhen Jiu. 2014 May;34(5):517-20.
Literatures of study on acupoint functional effect of encephalic region with functional magnetic resonance imaging (fMRI) are collected from the database of China National Knowledge Information (CNKI) and Wan fang database. Analysis and comments are made respectively from the status quo of studies on combination of single acupoint, two acupoints and multiple acupoints under both physiological and pathological conditions. The results show that the corresponding encephalic regions can be specifically activated by acupuncture. And different regions can be activated by different acupoints. However, studies on single acupoint, two acupoints and three acupoints are the major researches carried out at present. It is still lack of observation on effect of commonly-used combinations in clinic. Moreover, the reliability of the research results are also affected by disunity of operations protocol, reinforcing or reducing manipulations, intensity or depth of stimulation and duration of needling retention. Therefore, it is necessary to establish a unified and standard operation protocol to strictly control the bias factors which may affect the result of research in the future, and take patients as the study target as much as possible, so as to further explore the central effect mechanism.
从中国知网（CNKI）数据库和万方数据库收集有关功能磁共振成像（fMRI）对脑区穴位功能效应研究的文献。分别从生理和病理条件下单穴位、双穴位及多穴位组合的研究现状进行分析和评述。结果表明，针刺可特异性激活相应脑区，不同穴位可激活不同脑区。然而，目前主要开展的是单穴位、双穴位和三穴位的研究，临床常用组合效应观察尚显不足。此外，研究结果的可靠性还受到操作规范、补泻手法、刺激强度或深度以及留针时间不统一的影响。因此，有必要建立统一规范的操作方案，严格控制未来可能影响研究结果的偏倚因素，并尽可能以患者为研究对象，进一步探索中枢效应机制。
