精选香料及其组合可调节实验大鼠高胆固醇血症诱导的氧化应激。
Selected spices and their combination modulate hypercholesterolemia-induced oxidative stress in experimental rats.
作者信息
Otunola Gloria A, Oloyede Oyelola B, Oladiji Adenike T, Afolayan Anthony J
出版信息
Biol Res. 2014 Mar 26;47(1):5. doi: 10.1186/0717-6287-47-5.
BACKGROUND
Effect of aqueous extracts of Allium sativum (garlic), Zingiber officinale (ginger), Capsicum fructensces (cayenne pepper) and their mixture on oxidative stress in rats fed high Cholesterol/high fat diet was investigated. Rats were randomly distributed into six groups (n=6) and given different dietary/spice treatments. Group 1 standard rat chow (control), group 2, hypercholesterolemic diet plus water, and groups 3, 4, 5, 6, hypercholesterolemic diet with 0.5 ml 200 mg · kg-1 aqueous extracts of garlic, ginger, cayenne pepper or their mixture respectively daily for 4 weeks.
RESULTS
Pronounced oxidative stress in the hypercholesterolemic rats evidenced by significant (p<0.05) increase in MDA levels, and suppression of the antioxidant enzymes system in rat's liver, kidney, heart and brain tissues was observed. Extracts of spices singly or combined administered at 200 mg.kg-1 body weight significantly (p<0.05) reduced MDA levels and restored activities of antioxidant enzymes.
CONCLUSIONS
It is concluded that consumption of garlic, ginger, pepper, or their mixture may help to modulate oxidative stress caused by hypercholesterolemia in rats.
背景
研究了大蒜、生姜、辣椒的水提取物及其混合物对高胆固醇/高脂肪饮食喂养大鼠氧化应激的影响。将大鼠随机分为六组（n = 6），给予不同的饮食/香料处理。第1组为标准大鼠饲料（对照组），第2组为高胆固醇饮食加饮用水，第3、4、5、6组为高胆固醇饮食，分别每日给予0.5 ml 200 mg·kg-1大蒜、生姜、辣椒水提取物或其混合物，持续4周。
结果
观察到高胆固醇血症大鼠存在明显的氧化应激，表现为丙二醛（MDA）水平显著升高（p<0.05），且大鼠肝脏、肾脏、心脏和脑组织中的抗氧化酶系统受到抑制。以200 mg·kg-1体重单独或联合给予香料提取物可显著降低MDA水平（p<0.05），并恢复抗氧化酶的活性。
结论
得出的结论是，食用大蒜、生姜、辣椒或其混合物可能有助于调节大鼠高胆固醇血症引起的氧化应激。
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