Center for Applied Biomechanics, Dept. of Mechanical and Aerospace Engineering, University of Virginia, USA.
Dept. of Biomedical Engineering, Duke University, USA.
Exp Neurol. 2014 Nov;261:120-6. doi: 10.1016/j.expneurol.2014.07.002. Epub 2014 Jul 14.
Scaling is an essential component for translating the clinical outcomes of a neurotrauma model to the human equivalent. This article reviews the principles of biomechanical scaling for traumatic brain injuries, and a number of different approaches to scaling the dose (inputs) and response (outputs) of an animal model to humans are highlighted. A particular focus on blast injury scaling is given as an ongoing area of research, and discussion on the implications of scaling on the current blast TBI literature is provided. The risk of using neurotrauma models without considering an appropriate scaling method is that injuries may be induced with non-realistic loading conditions, and the injury mechanisms produced in the laboratory may not be consistent with those in the clinical setting.
标度是将神经创伤模型的临床结果转化为人类等效物的重要组成部分。本文回顾了创伤性脑损伤的生物力学标度原则，并强调了几种不同的方法来将动物模型的剂量（输入）和反应（输出）标度到人类。特别关注爆炸伤的标度，因为这是一个正在进行的研究领域，并讨论了标度对当前爆炸性创伤性脑损伤文献的影响。如果不考虑适当的标度方法而使用神经创伤模型，可能会导致受伤情况在不现实的加载条件下发生，并且实验室中产生的损伤机制可能与临床环境中的不一致。
