Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Molecular and Clinical Medicine/Multidisciplinary Pain Center, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):964-972. doi: 10.1016/j.ijrobp.2014.04.030. Epub 2014 Jul 8.
Patients treated with radiation therapy for laryngeal cancer often experience voice problems. The aim of this randomized controlled trial was to assess the efficacy of voice rehabilitation for laryngeal cancer patients after having undergone radiation therapy and to investigate whether differences between different tumor localizations with regard to rehabilitation outcomes exist.
Sixty-nine male patients irradiated for laryngeal cancer participated. Voice recordings and self-assessments of communicative dysfunction were performed 1 and 6 months after radiation therapy. Thirty-three patients were randomized to structured voice rehabilitation with a speech-language pathologist and 36 to a control group. Furthermore, comparisons with 23 healthy control individuals were made. Acoustic analyses were performed for all patients, including the healthy control individuals. The Swedish version of the Self Evaluation of Communication Experiences after Laryngeal Cancer and self-ratings of voice function were used to assess vocal and communicative function.
The patients who received vocal rehabilitation experienced improved self-rated vocal function after rehabilitation. Patients with supraglottic tumors who received voice rehabilitation had statistically significant improvements in voice quality and self-rated vocal function, whereas the control group did not.
Voice rehabilitation for male patients with laryngeal cancer is efficacious regarding patient-reported outcome measurements. The patients experienced better voice function after rehabilitation. Patients with supraglottic tumors also showed an improvement in terms of acoustic voice outcomes. Rehabilitation with a speech-language pathologist is recommended for laryngeal cancer patients after radiation therapy, particularly for patients with supraglottic tumors.
接受放射治疗的喉癌患者常出现嗓音问题。本随机对照试验旨在评估喉癌患者接受放射治疗后的嗓音康复效果，并探讨不同肿瘤部位的康复效果是否存在差异。
69 名男性喉癌放疗患者参与了本研究。放疗后 1 个月和 6 个月进行嗓音录音和交流障碍自我评估。33 名患者随机分配至言语治疗师进行结构化嗓音康复，36 名患者分配至对照组。此外，还与 23 名健康对照者进行了比较。对所有患者（包括健康对照组）进行了声学分析。使用瑞典版喉癌后交流体验自评量表和嗓音功能自评量表评估嗓音和交流功能。
接受嗓音康复的患者在康复后自我评估的嗓音功能得到改善。接受嗓音康复的声门上型肿瘤患者的嗓音质量和自我评估的嗓音功能有统计学意义的改善，而对照组则没有。
对于喉癌男性患者，嗓音康复在患者报告的结局测量方面是有效的。患者在康复后嗓音功能得到改善。声门上型肿瘤患者的嗓音声学结果也有所改善。建议喉癌患者在放疗后接受言语治疗师的康复治疗，特别是声门上型肿瘤患者。
