Karlsson Therese, Johansson Mia, Andréll Paulin, Finizia Caterina
Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital , Gothenburg , Sweden.
Acta Oncol. 2015 Jul;54(7):1017-24. doi: 10.3109/0284186X.2014.995773. Epub 2015 Jan 23.
This study aims to assess the effect of voice rehabilitation on health-related quality of life (HRQL) and communication experience for laryngeal cancer patients treated with radiotherapy.
This prospective randomised controlled trial included 74 patients with Tis-T4 laryngeal cancer treated curatively by radiotherapy, of which 37 constituted the intervention group receiving voice rehabilitation and 37 patients as a control group. Patients were followed at one and six months post-radiotherapy, with voice rehabilitation conducted between these time-points. Endpoints included patient reported outcomes, including HRQL as measured by European Organisation for Research and Treatment of Cancer (EORTC) Core30 (C30) and Head & Neck35 (H&N35) as well as communication function as measured by Swedish Self-Evaluation of Communication Experiences after Laryngeal cancer (S-SECEL).
The intervention group reported statistically significant improvements in communication experience as measured by S-SECEL environmental, attitudinal and total score domains compared to the control group. Similar improvements were seen in EORTC H&N35 Speech domain and the EORTC C30 domain Global quality of life. Moderate correlations were noted (r = 0.51-0.59) between three of four S-SECEL domains and the EORTC domains Speech and Global quality of life.
Laryngeal cancer patients treated with radiotherapy who receive voice rehabilitation appear to experience beneficial effects on communication function and selected HRQL domains. Voice rehabilitation following radiotherapy is recommended but further research investigating potential target groups and long-term effects is required.
本研究旨在评估嗓音康复对接受放射治疗的喉癌患者健康相关生活质量（HRQL）和沟通体验的影响。
这项前瞻性随机对照试验纳入了74例接受根治性放射治疗的Tis-T4期喉癌患者，其中37例构成接受嗓音康复的干预组，37例患者作为对照组。在放疗后1个月和6个月对患者进行随访，在这两个时间点之间进行嗓音康复。终点包括患者报告的结局，包括由欧洲癌症研究与治疗组织（EORTC）核心30（C30）和头颈35（H&N35）测量的HRQL，以及由瑞典喉癌后沟通体验自我评估（S-SECEL）测量的沟通功能。
与对照组相比，干预组在S-SECEL环境、态度和总分领域测量的沟通体验方面有统计学意义的改善。在EORTC H&N35言语领域和EORTC C30领域总体生活质量方面也有类似改善。在四个S-SECEL领域中的三个与EORTC言语和总体生活质量领域之间观察到中度相关性（r = 0.51-0.59）。
接受嗓音康复的放射治疗喉癌患者似乎在沟通功能和选定的HRQL领域有有益影响。建议放疗后进行嗓音康复，但需要进一步研究潜在目标群体和长期影响。
