Sajun Merchant Shaziya Z, Vaidya Ashlesha D, Salvi Anjali, Joshi Rajiv S, Mohile Rashmikant B
Department of Clinical Research, CLAIMS Pvt. Ltd., Mumbai, Maharashtra, India.
Indian J Dermatol Venereol Leprol. 2014 Jul-Aug;80(4):291-5. doi: 10.4103/0378-6323.136830.
A good patch test system should have good adhesion and contact, and minimal leakage; Finn and IQ patch test system have these properties but are expensive.
To develop a new cost-effective occlusive patch test system that had good contact with the skin and was non-irritant.
The system (designated Chamber X) was fabricated using a semi-permeable tape and a flexible virgin plastic chamber. Chamber X was developed by (i) selecting adhesive tape based on its non irritancy and adhesive potential (ii) testing plastic chamber material for its skin irritancy (iii) testing the assembled system against Finn, IQ and locally available chambers for irritancy, contact, leakage and occlusivity.
Chamber X showed better occlusion than IQ, Finn and locally available chambers and was comparable to, (P > 0.05) IQ and Finn in terms of irritancy, contact and leakage.
The results demonstrate that the Chamber X offers a cost effective patch test system comparable to IQ and Finn chambers in terms of safety, adhesion, leakage and occlusivity.
一个良好的斑贴试验系统应具备良好的粘附性和接触性，且渗漏极少；芬兰斑贴试验系统和IQ斑贴试验系统具备这些特性，但价格昂贵。
研发一种新型的经济高效的封闭性斑贴试验系统，该系统与皮肤接触良好且无刺激性。
该系统（命名为X型腔室）采用半透性胶带和柔性原生塑料腔体制成。X型腔室的研发过程包括：(i) 根据胶带的无刺激性和粘附潜力选择胶带；(ii) 测试塑料腔室材料的皮肤刺激性；(iii) 将组装好的系统与芬兰斑贴试验系统、IQ斑贴试验系统以及当地可得的腔室进行刺激性、接触性、渗漏性和封闭性测试。
X型腔室的封闭性优于IQ斑贴试验系统、芬兰斑贴试验系统和当地可得的腔室，在刺激性、接触性和渗漏性方面与IQ斑贴试验系统和芬兰斑贴试验系统相当（P>0.05）。
结果表明，X型腔室提供了一种经济高效的斑贴试验系统，在安全性、粘附性、渗漏性和封闭性方面与IQ斑贴试验系统和芬兰斑贴试验系统相当。
