Bagley D M, Boisits E K, Spriggs T L, Schwartz S
Colgate-Palmolive Company, Piscataway, NJ 08855-1343, USA.
Am J Contact Dermat. 2001 Mar;12(1):25-7. doi: 10.1053/ajcd.2000.8010.
Many different patch systems are available for predicting contact dermatitis. It is important to determine the ideal patch to meet the objective of the testing method.
The 21-day cumulative irritation test is well accepted for predicting irritation after repeated exposures. The patch type must allow separation of materials to predict irritation potential in the marketplace. Three patch systems were compared to determine which best provides this separation and prediction.
Four test materials were evaluated using 3 patch systems in a 21-day cumulative irritation test. Tested were water, 0.06% sodium lauryl sulfate (SLS), and 2 underarm products (UAP), one having lower and one having higher irritation potential. The patch types were; Webril pad and 8-mm and 12-mm Finn Chambers.
Both the 12-mm Finn Chamber and Webril pad showed the ability to differentiate the higher irritating UAP and the 0.06% SLS from the lower irritation UAP product and water. The 8-mm Finn chamber was less discriminating, showing the 0.06% SLS to be the same as water and the lower-irritating UAP.
The Webril pad and the 12-mm Finn Chamber are better at discriminating irritation potential than is the 8-mm Finn Chamber. The 12-mm Finn Chamber might also allow discrimination with a lower degree of irritation.
有许多不同的贴片系统可用于预测接触性皮炎。确定理想的贴片以满足测试方法的目标很重要。
21天累积刺激试验在预测重复暴露后的刺激性方面得到广泛认可。贴片类型必须能够分离材料，以预测市场上产品的刺激潜力。比较了三种贴片系统，以确定哪种系统能最好地实现这种分离和预测。
在21天累积刺激试验中，使用3种贴片系统对4种测试材料进行评估。测试材料为水、0.06%月桂醇硫酸酯钠（SLS）和2种腋下产品（UAP），其中一种刺激性较低，另一种刺激性较高。贴片类型为：Webril垫以及8毫米和12毫米的Finn Chambers。
12毫米的Finn Chambers和Webril垫都能够区分刺激性较高的UAP以及0.06%的SLS与刺激性较低的UAP产品和水。8毫米的Finn Chambers区分能力较差，显示0.06%的SLS与水以及刺激性较低的UAP相同。
Webril垫和12毫米的Finn Chambers在区分刺激潜力方面比8毫米的Finn Chambers更好。12毫米的Finn Chambers也可能在较低刺激程度下实现区分。
