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汉坦病毒:英国急性肾损伤的一种感染性病因。

Hantavirus: an infectious cause of acute kidney injury in the UK.

作者信息

Adams Kate, Jameson Lisa, Meigh Rolf, Brooks Tim

机构信息

Department of Infection, Castle Hill Hospital, Cottingham, East Yorkshire, UK.

Rare and Imported Pathogens Laboratory, Salisbury, Wiltshire, UK.

出版信息

BMJ Case Rep. 2014 Jul 17;2014:bcr2014205529. doi: 10.1136/bcr-2014-205529.

Abstract

We present a case of an undifferentiated febrile illness in a 59-year-old man from East Yorkshire. He was initially treated for leptospirosis due to the fact that he had farm exposure and the findings of acute kidney injury (AKI), thrombocytopenia and a raised alanine transferase (ALT) on his initial blood results. Serology tests later proved him to have had another rodent-borne illness: hantavirus. An investigation by Public Health England (formerly known as Health Protection Agency) (PHE) went on to prove the presence of the same serotype of hantavirus in rats caught on the patient's property. After an initial deterioration, the patient made a relatively uneventful recovery and all his blood tests returned to normal levels.

摘要

我们报告一例来自东约克郡的59岁男性不明原因发热疾病的病例。由于他有农场接触史,且初始血液检查结果显示存在急性肾损伤(AKI)、血小板减少和丙氨酸转氨酶(ALT)升高,他最初被诊断为钩端螺旋体病并接受治疗。血清学检测后来证实他感染了另一种鼠传疾病:汉坦病毒。英国公共卫生署(前身为健康保护局)(PHE)的一项调查进一步证明,在患者住所捕获的大鼠中存在相同血清型的汉坦病毒。经过最初的病情恶化后,患者恢复过程相对平稳,所有血液检查结果均恢复到正常水平。

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本文引用的文献

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UK hantavirus, renal failure, and pet rats.英国汉坦病毒、肾衰竭与宠物鼠。
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Nat Clin Pract Nephrol. 2006 Jul;2(7):364-77. doi: 10.1038/ncpneph0218.

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