从泼尼松到幽门螺杆菌：一例幽门螺杆菌诱导的慢性免疫性血小板减少症
From prednisone to pylori: a case of Helicobacter pylori-induced chronic immune thrombocytopenia.
作者信息
Hill Larisa J N, Tung Ericka E
机构信息
Mayo Medical School, Rochester, Minnesota, USA.
The Division of Primary Care Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
出版信息
BMJ Case Rep. 2014 Jul 17;2014:bcr2014205786. doi: 10.1136/bcr-2014-205786.
Abstract
A 54-year-old woman was seen by her primary care internist for a general health maintenance visit. Her major chronic illness was immune thrombocytopenic purpura (ITP) for which she had been treated with prednisone therapy for the past 15 years. Recent review of possible aetiologies of her chronic thrombocytopenia revealed infection with Helicobacter pylori. Successful eradication resulted in complete resolution of her thrombocytopenia within 2 months. She was weaned from steroid therapy and at 1-year follow-up, her platelet counts remained in the normal range. This case report summarises what is known about the association of H. pylori infection and ITP.
摘要
一位54岁女性因进行常规健康检查就诊于其初级保健内科医生处。她的主要慢性病是免疫性血小板减少性紫癜（ITP），在过去15年中一直接受泼尼松治疗。最近对其慢性血小板减少症可能病因的检查发现感染了幽门螺杆菌。成功根除幽门螺杆菌后，她的血小板减少症在2个月内完全缓解。她逐渐停用了类固醇治疗，在1年的随访中，她的血小板计数仍保持在正常范围内。本病例报告总结了关于幽门螺杆菌感染与ITP关联的已知情况。
相似文献
1
From prednisone to pylori: a case of Helicobacter pylori-induced chronic immune thrombocytopenia.从泼尼松到幽门螺杆菌：一例幽门螺杆菌诱导的慢性免疫性血小板减少症
BMJ Case Rep. 2014 Jul 17;2014:bcr2014205786. doi: 10.1136/bcr-2014-205786.
2
Helicobacter pylori infection and idiopathic thrombocytopenic purpura.幽门螺杆菌感染与特发性血小板减少性紫癜
Int J Hematol. 2005 Feb;81(2):113-8. doi: 10.1532/ijh97.04161.
3
Is eradication therapy useful as the first line of treatment in Helicobacter pylori-positive idiopathic thrombocytopenic purpura? Analysis of 207 eradicated chronic ITP cases in Japan.根除疗法作为幽门螺杆菌阳性的特发性血小板减少性紫癜的一线治疗方法是否有用？对日本207例已根除幽门螺杆菌的慢性免疫性血小板减少症病例的分析。
Int J Hematol. 2005 Feb;81(2):162-8. doi: 10.1532/ijh97.04146.
4
Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura.特发性血小板减少性紫癜患者根除幽门螺杆菌后的血小板恢复情况。
Ann Hematol. 2003 Jan;82(1):30-2. doi: 10.1007/s00277-002-0579-8. Epub 2002 Dec 17.
5
Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura.慢性特发性血小板减少性紫癜患者根除幽门螺杆菌感染后血小板反应缺失。
Br J Haematol. 2001 Dec;115(4):1002-3. doi: 10.1046/j.1365-2141.2001.03194.x.
6
Characteristics of Helicobacter pylori-induced gastritis and the effect of H. pylori eradication in patients with chronic idiopathic thrombocytopenic purpura.幽门螺杆菌感染性胃炎的特征以及幽门螺杆菌根除对慢性特发性血小板减少性紫癜患者的影响。
Helicobacter. 2004 Oct;9(5):443-52. doi: 10.1111/j.1083-4389.2004.00261.x.
7
8
Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography.免疫性血小板减少性紫癜患者幽门螺杆菌根除治疗：综述及生物地理学的作用
Helicobacter. 2015 Aug;20(4):239-51. doi: 10.1111/hel.12200. Epub 2015 Mar 1.
9
Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura.幽门螺杆菌根除治疗在特发性血小板减少性紫癜患者管理中的应用
Am J Med. 2005 Apr;118(4):414-9. doi: 10.1016/j.amjmed.2004.09.014.
10
Helicobacter pylori infection and chronic immune thrombocytopenic purpura: long-term results of bacterium eradication and association with bacterium virulence profiles.幽门螺杆菌感染与慢性免疫性血小板减少性紫癜：细菌根除的长期结果及与细菌毒力谱的关联
Blood. 2007 Dec 1;110(12):3833-41. doi: 10.1182/blood-2006-12-063222. Epub 2007 Jul 24.
引用本文的文献
1
Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review.幽门螺杆菌感染诱发的免疫性血小板减少症：一例报告及文献综述
Cureus. 2025 Apr 13;17(4):e82167. doi: 10.7759/cureus.82167. eCollection 2025 Apr.
2
Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review.幽门螺杆菌感染诱发的免疫性血小板减少症：一例报告及文献综述
Cureus. 2022 Aug 9;14(8):e27809. doi: 10.7759/cureus.27809. eCollection 2022 Aug.
3
Helicobacter pylori: An Underrated Cause of Immune Thrombocytopenic Purpura. A Comprehensive Review.幽门螺杆菌：免疫性血小板减少性紫癜的一个被低估的病因。一篇综述。
Cureus. 2019 Sep 1;11(9):e5551. doi: 10.7759/cureus.5551.
本文引用的文献
1
Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.幽门螺杆菌相关的慢性胃炎、临床综合征、癌前病变及胃癌发生的发病机制。
World J Gastroenterol. 2014 May 14;20(18):5461-73. doi: 10.3748/wjg.v20.i18.5461.
2
The role of Helicobacter pylori infection in hematological disorders.幽门螺杆菌感染与血液系统疾病。
Eur J Intern Med. 2013 Dec;24(8):685-90. doi: 10.1016/j.ejim.2013.02.011. Epub 2013 Mar 21.
3
Platelet Count Response to Helicobacter pylori Eradication in Iranian Patients with Idiopathic Thrombocytopenic Purpura.伊朗特发性血小板减少性紫癜患者幽门螺杆菌根除后血小板计数反应。
Mediterr J Hematol Infect Dis. 2012;4(1):e2012056. doi: 10.4084/MJHID.2012.056. Epub 2012 Aug 10.
4
Immune thrombocytopenia in adults: an update.成人免疫性血小板减少症：更新。
Cleve Clin J Med. 2012 Sep;79(9):641-50. doi: 10.3949/ccjm.79a.11027.
5
Extragastrointestinal manifestations of Helicobacter pylori infection: facts or myth? A critical review.幽门螺杆菌感染的胃肠道外表现：事实还是虚构？批判性综述。
J Dig Dis. 2012 Jul;13(7):342-9. doi: 10.1111/j.1751-2980.2012.00599.x.
6
Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report.幽门螺杆菌感染的管理——马斯特里赫特 IV/佛罗伦萨共识报告。
Gut. 2012 May;61(5):646-64. doi: 10.1136/gutjnl-2012-302084.
7
The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia.美国血液学会 2011 年免疫性血小板减少症循证实践指南。
Blood. 2011 Apr 21;117(16):4190-207. doi: 10.1182/blood-2010-08-302984. Epub 2011 Feb 16.
8
Effects of Helicobacter pylori eradication in patients with immune thrombocytopenic purpura.幽门螺杆菌根除对免疫性血小板减少性紫癜患者的影响。
Korean J Hematol. 2010 Jun;45(2):127-32. doi: 10.5045/kjh.2010.45.2.127. Epub 2010 Jun 30.
9
Eight-year follow-up of patients with immune thrombocytopenic purpura related toH. pyloriinfection.与 H. pylori 感染相关的免疫性血小板减少性紫癜患者的 8 年随访。
Platelets. 2011;22(1):61-4. doi: 10.3109/09537104.2010.515272. Epub 2010 Oct 13.
10
The ITP syndrome: pathogenic and clinical diversity.免疫性血小板减少症综合征：发病机制与临床多样性
Blood. 2009 Jun 25;113(26):6511-21. doi: 10.1182/blood-2009-01-129155. Epub 2009 Apr 24.
Zotero 插件