Chandra Ivatury Sarath, Kumar Kalasapati Lokesh, Reddy Mallepalli Pramod, Reddy Chada Muni Pavan Kumar
Department of Psychiatry, Mamata General Hospital, Khammam, Andhra Pradesh, India.
Department of Psychiatry, Bhaskara Medical College, Hyderabad, Andhra Pradesh, India.
Indian J Psychol Med. 2014 Jul;36(3):294-8. doi: 10.4103/0253-7176.135383.
Non-compliance for the medication is an important area of concern in schizophrenia as it contributes to relapse and re-hospitalization of the patients. One of the ways to improve the drug compliance is to know crucial factors responsible for poor drug compliance and hence that proper strategies may be planned to improve patient's drug compliance.
The aim of the following study is to find out the attitudes of patients toward medication and reasons for drug non-compliance in schizophrenia and its association with clinical and socio-demographic variables.
The study was conducted on follow-up patients with schizophrenia for the duration of 5 months. Their socio-demographic details were noted and illness related variables were evaluated using Positive and Negative Syndrome scale (PANSS). Patient's attitudes toward medication and the reasons for treatment non-compliance were assessed using the standardized tools, which consist of Drug Attitude Inventory-10 scale and Rating of Medication Influences scale respectively.
Nearly 41.9% of our study sample were non-compliant to medication. A significant association has been found between non-compliance and younger age group, unemployment, early age of onset, high positive PANSS score and poorer insight into the illness. The significant reasons for non-compliance in our study were Denial of illness, financial burden, less access to treatment facilities, Side-effects of the medication, Feeling that the medication was unnecessary and Substance abuse.
Findings suggest that there is a need to provide adequate information about mental illness and medications prescribed, to enhance medication compliance and to develop community mental health care facilities.
药物治疗不依从是精神分裂症中一个重要的关注领域，因为它会导致患者复发和再次住院。提高药物依从性的方法之一是了解导致药物依从性差的关键因素，从而制定适当的策略来提高患者的药物依从性。
以下研究的目的是了解精神分裂症患者对药物治疗的态度、药物不依从的原因及其与临床和社会人口统计学变量的关联。
该研究对精神分裂症随访患者进行了为期5个月的观察。记录他们的社会人口统计学细节，并使用阳性和阴性症状量表（PANSS）评估与疾病相关的变量。分别使用标准化工具，即药物态度量表-10和药物影响评分量表，评估患者对药物治疗的态度和治疗不依从的原因。
我们研究样本中近41.9%的患者存在药物治疗不依从情况。研究发现，不依从与较年轻的年龄组、失业、发病年龄早、PANSS阳性评分高以及对疾病的洞察力较差之间存在显著关联。我们研究中不依从的重要原因包括否认患病、经济负担、获得治疗设施的机会少、药物副作用、认为药物不必要以及药物滥用。
研究结果表明，有必要提供关于精神疾病和所开药物的充分信息，以提高药物依从性，并发展社区精神卫生保健设施。
