瑜伽对哮喘患者生化指标的影响：一项随机对照研究。
Impact of yoga on biochemical profile of asthmatics: A randomized controlled study.
作者信息
Agnihotri Shruti, Kant Surya, Kumar Santosh, Mishra Ranjeet K, Mishra Satyendra K
机构信息
Department of Pulmonary Medicine, King George's Medical University, Uttar Pradesh, Lucknow, Uttar Pradesh, India.
Department of Biochemistry, Lucknow University, Lucknow, Uttar Pradesh, India.
出版信息
Int J Yoga. 2014 Jan;7(1):17-21. doi: 10.4103/0973-6131.123473.
BACKGROUND
Asthma is a chronic inflammatory disorder of the airways. The chronic inflammation causes an associated increase in airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing at night or in the early morning. Most of the studies have reported, as the effects of yoga on bronchial asthma, significant improvements in pulmonary functions, quality of life, and decrease in medication use, but none of the studies has attempted to show the effect of yoga on biochemical changes.
OBJECTIVE
To evaluate the effect of yoga on biochemical profile of asthmatics.
MATERIALS AND METHODS
In the present study, 276 patients of mild to moderate asthma (FEV 1> 60%) aged between 12 to 60 years were recruited from the Department of Pulmonary Medicine, King George's Medical University, U.P., Lucknow, India. They were randomly divided into two groups: Yoga group (with standard medical treatment and yogic intervention) and control group as standard medical treatment (without yogic intervention). At completion of 6 months of the study period, 35 subjects were dropped out, so out of 276 subjects, only 241 subjects completed the whole study (121 subjects from yoga group and 120 subjects from control group). Biochemical assessment was carried out at baseline and after 6 months of the study period.
RESULTS
In yoga group, there was significant improvement found in the proportion of hemoglobin and antioxidant superoxide dismutase in comparison to control group and significant decrease was found in total leukocyte count (TLC) and differential leukocytes count in comparison to control group. There was no significant change found in TLC, polymorphs, and monocytes in between group comparison.
CONCLUSIONS
Yoga group got significantly better improvement in biochemical variables than control group. Result shows that yoga can be practiced as adjuvant therapy with standard inhalation therapy for better outcome of asthma.
背景
哮喘是一种气道慢性炎症性疾病。这种慢性炎症会导致气道高反应性相应增加，进而引发夜间或清晨反复出现喘息、气促、胸闷和咳嗽症状。大多数研究报告了瑜伽对支气管哮喘的影响，包括肺功能显著改善、生活质量提高以及药物使用减少，但尚无研究试图证明瑜伽对生化变化的影响。
目的
评估瑜伽对哮喘患者生化指标的影响。
材料与方法
在本研究中，从印度勒克瑙市乔治国王医科大学肺病科招募了276例年龄在12至60岁之间的轻至中度哮喘患者（第一秒用力呼气容积>60%）。他们被随机分为两组：瑜伽组（接受标准药物治疗和瑜伽干预）和对照组（仅接受标准药物治疗，无瑜伽干预）。在6个月的研究期结束时，有35名受试者退出，因此在276名受试者中，只有241名受试者完成了整个研究（瑜伽组121名受试者，对照组120名受试者）。在研究期开始时和6个月后进行生化评估。
结果
与对照组相比，瑜伽组血红蛋白和抗氧化超氧化物歧化酶比例有显著改善，总白细胞计数（TLC）和分类白细胞计数显著降低。组间比较发现，TLC、多形核白细胞和单核细胞无显著变化。
结论
瑜伽组在生化指标方面的改善明显优于对照组。结果表明，瑜伽可作为标准吸入疗法的辅助治疗方法，以获得更好的哮喘治疗效果。
Zotero 插件