Rodrigo C, Chau M, Rosenquist J
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Hong Kong.
Int J Oral Maxillofac Surg. 1989 Jun;18(3):130-2. doi: 10.1016/s0901-5027(89)80107-9.
A double-blind randomised cross-over study to compare 2 regimes of paracetamol and diflunisal for postoperative pain relief following 3rd molar surgery was designed. 35 patients received one of the regimes at one visit and the alternative at the other visit. Both drugs, namely a single dose of 500 mg of diflunisal given preoperatively or 2 doses of 1000 mg of paracetamol, given preoperatively and 4 h postoperatively, produced adequate pain relief, without the need for supplementary analgesics during the 10-h test period. The differences in the mean overall pain scores in the 2 regimes were not statistically significant.
设计了一项双盲随机交叉研究，以比较两种对乙酰氨基酚和二氟尼柳方案用于第三磨牙手术后疼痛缓解的效果。35名患者在一次就诊时接受其中一种方案，在另一次就诊时接受另一种方案。两种药物，即术前给予单剂量500mg二氟尼柳或术前及术后4小时给予2剂1000mg对乙酰氨基酚，均能产生足够的疼痛缓解，在10小时的测试期内无需补充镇痛药。两种方案的平均总体疼痛评分差异无统计学意义。
