Rodrigo M R, Rosenquist J B, Cheung L K
Oral Surgery, Faculty of Dentistry, University of Hong Kong, Prince Philip Dental Hospital.
Int J Oral Maxillofac Surg. 1987 Oct;16(5):566-71. doi: 10.1016/s0901-5027(87)80107-8.
In a double blind study in Hong Kong Chinese, 250 mg of diflunisal, 500 mg of paracetamol or placebo were given for post-operative pain relief following 77 third molar surgical procedures. The intensity of pain was recorded on a visual analogue scale. The first and second doses of paracetamol reduced pain significantly more than placebo, while this was true only for the second dose of diflunisal. There was no significant difference in pain reduction with the first and second dose of paracetamol, when compared with the first and the second dose of diflunisal. In this study in Hong Kong Chinese, neither the dose nor the interval between ingestion of the analgesic tablets in patients, who needed analgesics for postoperative pain, were significantly different to that reported before in non-Chinese, in contrast to the popular belief that Chinese patients have higher pain thresholds. However, a higher proportion of Chinese than that reported in non-Chinese did not need any analgesics for relief of postoperative pain.
在一项针对香港华人的双盲研究中，对77例接受第三磨牙外科手术的患者给予250毫克双氟尼柳、500毫克对乙酰氨基酚或安慰剂，以缓解术后疼痛。疼痛强度通过视觉模拟量表记录。对乙酰氨基酚的第一剂和第二剂比安慰剂能更显著地减轻疼痛，而双氟尼柳仅在第二剂时有此效果。与双氟尼柳的第一剂和第二剂相比，对乙酰氨基酚的第一剂和第二剂在减轻疼痛方面没有显著差异。在这项针对香港华人的研究中，需要术后镇痛的患者服用止痛片的剂量和间隔时间与之前非华人的报道相比均无显著差异，这与普遍认为华人患者疼痛阈值更高的观点相反。然而，与非华人的报道相比，有更高比例的华人患者术后疼痛无需任何止痛药物缓解。
