Rodrigo M R, Rosenquist J B
Department of Oral Surgery and Oral Medicine, University of Hong Kong.
Aust Dent J. 1990 Aug;35(4):333-7. doi: 10.1111/j.1834-7819.1990.tb00781.x.
A randomized cross-over study was carried out to determine whether midazolam in doses used for conscious sedation had any effect on the potency or duration of diflunisal, a non-narcotic analgesic used for postoperative pain in oral surgery. Thirty-two Hong Kong Chinese patients of either sex, aged between 16 and 28 years, were given either midazolam to supplement local anaesthesia or local anaesthesia alone at one visit and the alternative at the other visit, for surgical removal of bilateral symmetrically impacted third molars. Surgery was carried out on one side only at each visit. Diflunisal was given for postoperative pain relief. Midazolam had no effect on the potency or duration of action of diflunisal. Independent of the method, more patients had better pain relief following the second procedure than following the first, probably due to a degree of adaptation to the pain, at the second visit.
进行了一项随机交叉研究，以确定用于清醒镇静的咪达唑仑剂量是否对双氯芬酸（一种用于口腔外科术后疼痛的非麻醉性镇痛药）的效力或持续时间有任何影响。32名年龄在16至28岁之间的香港华裔患者，无论男女，在一次就诊时接受咪达唑仑补充局部麻醉或仅接受局部麻醉，而在另一次就诊时接受另一种方式，用于手术拔除双侧对称阻生的第三磨牙。每次就诊仅在一侧进行手术。给予双氯芬酸以缓解术后疼痛。咪达唑仑对双氯芬酸的效力或作用持续时间没有影响。无论采用何种方法，更多患者在第二次手术后的疼痛缓解情况比第一次更好，这可能是由于在第二次就诊时对疼痛有一定程度的适应。
