Jinno Shinji, Nakamura Yoshitaka, Nagata Masashi, Takahashi Takeshi
a Nutrition Research Department, Food Science Research Laboratories, Division of Research and Development , Meiji Co., Ltd. , Odawara , Japan.
Biosci Biotechnol Biochem. 2014;78(5):861-6. doi: 10.1080/09168451.2014.905179. Epub 2014 May 15.
To examine the effect of dietary supplementation with 1-kestose on the IgA levels in milk, BALB/c mice were fed diets with or without 5% 1-kestose during pregnancy and lactation. The total and specific IgA levels in the milk were measured at 7 and 14 days after delivery. A two-way ANOVA with repeated measures resulted in a significant effect of 1-kestose-supplementation on total IgA concentrations (p < 0.05) and the level of anti-Bacteroides IgA (p < 0.05). A significant positive correlation was found between the mean count of Bacteroides spp. in maternal feces and the total IgA concentration in maternal milk (r = 0.55, p < 0.05), suggesting a potential link between the gut and mammary gland immune system. In conclusion, this study demonstrated the effects of dietary prebiotics on milk IgA production.
为研究膳食补充1-蔗果三糖对牛奶中IgA水平的影响，在怀孕和哺乳期间，给BALB/c小鼠喂食含或不含5% 1-蔗果三糖的日粮。在分娩后7天和14天测量牛奶中的总IgA和特异性IgA水平。重复测量的双向方差分析结果显示，补充1-蔗果三糖对总IgA浓度（p < 0.05）和抗拟杆菌IgA水平（p < 0.05）有显著影响。在母体粪便中拟杆菌属的平均计数与母体牛奶中的总IgA浓度之间发现显著正相关（r = 0.55，p < 0.05），表明肠道和乳腺免疫系统之间存在潜在联系。总之，本研究证明了膳食益生元对牛奶IgA产生的影响。
