Jinno Shinji, Toshimitsu Takayuki, Nakamura Yoshitaka, Kubota Takayuki, Igoshi Yuka, Ozawa Naoko, Suzuki Shuichi, Nakano Taiji, Morita Yoshinori, Arima Takayasu, Yamaide Fumiya, Kohno Yoichi, Masuda Kentaro, Shimojo Naoki
Food Science Research Laboratories, R&D Division, Meiji Co., Ltd., 540 Naruda, Odawaara Kanagawa 250-0862, Japan.
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Nutrients. 2017 Feb 26;9(3):196. doi: 10.3390/nu9030196.
Fructooligosaccharides (FOS) can selectively stimulate the growth of bifidobacteria. Here, we investigated the effect of maternal FOS ingestion on maternal and neonatal gut bifidobacteria. In a randomized, double-blind, placebo-controlled study, we administered 8 g/day of FOS or sucrose to 84 women from the 26th week of gestation to one month after delivery. The bifidobacteria count was detected using quantitative PCR in maternal (26 and 36 weeks of gestation) and neonatal (one month after delivery) stools. Maternal stool frequency was recorded from 24 to 36 weeks of gestation. The number of fecal spp. and in the FOS group was significantly higher than that in the placebo group at 36 weeks of gestation (2.7 × 10/g vs. 1.1 × 10/g and 2.3 × 10/g vs. 9.7 × 10⁸/g). In their neonates, these numbers did not differ between the groups. Also, stool frequency in the FOS group was slightly higher than that in the placebo group two weeks after the intervention (1.0 vs. 0.8 times/day), suggesting a potential constipation alleviation effect. In conclusion, the maternal FOS ingestion showed a bifidogenic effect in pregnant women but not in their neonates.
低聚果糖（FOS）可以选择性地刺激双歧杆菌的生长。在此，我们研究了母体摄入低聚果糖对母体和新生儿肠道双歧杆菌的影响。在一项随机、双盲、安慰剂对照研究中，我们从妊娠第26周开始至产后1个月，给84名女性每天服用8克低聚果糖或蔗糖。使用定量PCR检测母体（妊娠26周和36周）和新生儿（产后1个月）粪便中的双歧杆菌数量。记录妊娠24至36周期间母体的排便频率。在妊娠36周时，低聚果糖组粪便中双歧杆菌的数量和种类显著高于安慰剂组（分别为2.7×10⁹/g对1.1×10⁹/g以及2.3×10⁹/g对9.7×10⁸/g）。在她们的新生儿中，两组之间这些数量没有差异。此外，干预两周后，低聚果糖组的排便频率略高于安慰剂组（分别为每天1.0次对0.8次），表明有潜在的缓解便秘作用。总之，母体摄入低聚果糖对孕妇有双歧杆菌生成作用，但对其新生儿没有。
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