PRC2 的 RNA 结合：杂乱无章还是井然有序？
RNA binding of PRC2: promiscuous or well ordered?
机构信息
Biochemistry Center Regensburg (BZR), University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany.
出版信息
Mol Cell. 2014 Jul 17;55(2):157-8. doi: 10.1016/j.molcel.2014.07.002.
PMID:25038410
Abstract
The polycomb repressive complex 2 (PRC2) methylates histones for epigenetic silencing and associates with thousands of protein-coding and noncoding RNAs. How the recruitment of PRC2 to specific sites is facilitated is currently unclear. Two recent studies have deciphered the impact of RNA binding on PRC2 recruitment and activity (Cifuentes-Rojas et al., 2014; Davidovich et al., 2013).
摘要
多梳抑制复合物 2（PRC2）通过组蛋白甲基化实现表观遗传沉默，并与数千种蛋白质编码和非编码 RNA 相关联。目前尚不清楚 PRC2 如何被招募到特定的位点。最近的两项研究揭示了 RNA 结合对 PRC2 招募和活性的影响（Cifuentes-Rojas 等人，2014 年；Davidovich 等人，2013 年）。
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