State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Guangzhou, China.
Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
J Exp Clin Cancer Res. 2019 May 16;38(1):198. doi: 10.1186/s13046-019-1213-0.
Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. Over the past decade, many studies have demonstrated the important regulatory roles of long non-coding RNAs (lncRNAs) in HCC. Here, we comprehensively review recent discoveries regarding HCC-associated lncRNA functions, which we have classified and described according to their mechanism models.
肝细胞癌（HCC）是全球最显著的致命恶性肿瘤之一。然而，该疾病起始和进展中涉及的分子机制仍知之甚少。在过去十年中，许多研究表明长非编码 RNA（lncRNA）在 HCC 中具有重要的调节作用。在这里，我们全面回顾了关于 HCC 相关 lncRNA 功能的最新发现，并根据其机制模型进行了分类和描述。
