[从耳叶牛皮消根中分离得到的C21甾体]
[C21 steroids from roots of Cynanchum otophyllum].
作者信息
Li Xiang, Zhang Mi, Xiang Cheng, Qin Yi, He Jing, Li Bao-Cai, Li Peng
出版信息
Zhongguo Zhong Yao Za Zhi. 2014 Apr;39(8):1450-6.
Eleven C21 steroids were isolated from chloroform extract of roots of Cynanchum otophyllumby silica gel, MCI, ODS columns, and semi-preparative HPLC. Their structures were determined by spectroscopic data analysis as otophylloside B(1), caudatin-3-O-beta-D-cymaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (2), caudatin-3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (3), caudatin-3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranosyl-(1-->4)-beta-D-cymaropyranoside (4), otophylloside O (5), gagamine-3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (6), sinomarinoside B (7), mucronatosides C (8), wallicoside J (9), stephanoside H (10), and qinyangshengenin-3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-cymaropyranosyl-(1-->4)-beta-D-digitoxopyranoside (11). Among them, compounds 2-3, and 6-11 were separated from the roots of this plant for the first time.
从青阳参根的氯仿提取物中，通过硅胶柱、MCI柱、ODS柱和半制备高效液相色谱法分离得到11种C21甾体化合物。通过光谱数据分析确定它们的结构分别为青阳参苷B（1）、考达定-3-O-β-D-磁麻糖基-（1→4）-β-D-夹竹桃糖基-（1→4）-β-D-磁麻糖基-（1→4）-β-D-磁麻糖苷（2）、考达定-3-O-β-D-夹竹桃糖基-（1→4）-β-D-夹竹桃糖基-（1→4）-β-D-磁麻糖基-（1→4）-β-D-磁麻糖苷（3）、考达定-3-O-β-D-夹竹桃糖基-（1→4）-β-D-洋地黄毒糖基-（1→4）-β-D-磁麻糖苷（4）、青阳参苷O（5）、加加明-3-O-β-D-夹竹桃糖基-（1→4）-β-D-磁麻糖基-（1→4）-β-D-磁麻糖苷（6）、中华夹竹桃苷B（7）、尖叶白前苷C（8）、娃儿藤苷J（9）、马莲鞍苷H（10）、以及青阳参苷元-3-O-β-D-夹竹桃糖基-（1→4）-β-D-磁麻糖基-（1→4）-β-D-洋地黄毒糖苷（11）。其中，化合物2 - 3以及6 - 11首次从该植物根部分离得到。
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