Hou Yanan, Wu Xuemin, Hallett Mark, Chan Piu, Wu Tao
Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
Hum Brain Mapp. 2014 Dec;35(12):5815-33. doi: 10.1002/hbm.22587. Epub 2014 Jul 12.
The brainstem and basal ganglia are important in the pathophysiology of Parkinson's disease (PD). Reliable and sensitive detection of neural activity changes in these regions should be helpful in scientific and clinical research on PD. In this study, we used resting state functional MRI and amplitude of low frequency fluctuation (ALFF) methods to examine spontaneous neural activity in 109 patients with PD. We examined activity in two frequency bands, slow-4 (between 0.027 and 0.073 Hz) and slow-5 (0.010-0.027 Hz). Patients had decreased ALFF in the striatum and increased ALFF in the midbrain, and changes were more significant in slow-4. Additionally, changes in slow-4 in both basal ganglia and midbrain correlated with the severity of the parkinsonism. The ALFF in the caudate nucleus positively correlated with the dose of levodopa, while the ALFF in the putamen negatively correlated with the disease duration in both slow-4 and slow-5 bands. In addition, the ALFF in the rostral supplementary motor area negatively correlated with bradykinesia subscale scores. Our findings show that with a large cohort of patients and distinguishing frequency bands, neural modulations in the brainstem and striatum in PD can be detected and may have clinical relevance. The physiological interpretation of these changes needs to be determined.
脑干和基底神经节在帕金森病（PD）的病理生理学中具有重要作用。可靠且灵敏地检测这些区域的神经活动变化，应有助于PD的科学研究和临床研究。在本研究中，我们采用静息态功能磁共振成像和低频振幅（ALFF）方法，对109例PD患者的自发神经活动进行了检测。我们检测了两个频段的活动，即慢波4（0.027至0.073赫兹之间）和慢波5（0.010 - 0.027赫兹）。患者纹状体的ALFF降低，中脑的ALFF升高，且在慢波4频段变化更为显著。此外，基底神经节和中脑慢波4频段的变化与帕金森综合征的严重程度相关。尾状核的ALFF与左旋多巴剂量呈正相关，而壳核的ALFF在慢波4和慢波5频段均与病程呈负相关。此外，喙部辅助运动区的ALFF与运动迟缓亚量表评分呈负相关。我们的研究结果表明，通过大量患者队列和区分频段，可以检测到PD患者脑干和纹状体的神经调制变化，且这些变化可能具有临床意义。这些变化的生理学解释有待确定。
