Department of Neurology, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Tianjin, 300222, China.
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China.
Neurol Sci. 2022 Oct;43(10):5909-5916. doi: 10.1007/s10072-022-06272-9. Epub 2022 Jul 15.
Resting-state functional magnetic resonance imaging (rs-fMRI) was widely used as an effective tool in the diagnosis of neurodegenerative diseases. However, prior rs-fMRI studies reported inconsistent results for comparison between Parkinson's disease (PD) and healthy controls (HC).
We searched studies published before December 2021 in databases (PubMed, Web of Science, and Google Scholar). An activation likelihood estimation (ALE) meta-analysis was made for functional changes in PD.
The study finally included 25 studies (including 973 PD patients and 766 HC). PD patients showed reduced amplitude of low frequency fluctuations (ALFF) in the left superior temporal gyrus (STG), the left superior frontal gyrus (SFG), the left medial frontal gyrus (MFG), the left precuneus (PCUN), and the right lentiform nucleus, compared to HC. PD patients showed increased ALFF in the right SFG, the left superior parietal lobule (SPL), the left STG, the right fusiform gyrus, the left inferior temporal gyrus (ITG), and the right parahippocampal gyrus (PHG), compared to HC. PD patients showed reduced regional homogeneity (ReHo) in the right declive, the right MFG, the left culmen, and the left thalamus, compared to HC. PD patients showed increased ReHo in the right SFG, compared to HC. Additionally, PD patients showed reduced functional connectivity (FC) in the right posterior cingulate (PCG), compared to HC.
The present ALE analysis has confirmed functional deficits in motor-, emotion-, and cognition-related regions in PD. Deficits in these regions in rs-fMRI studies could play a role in early diagnosis of PD.
静息态功能磁共振成像（rs-fMRI）已广泛应用于神经退行性疾病的诊断，是一种有效的工具。然而，先前的 rs-fMRI 研究在帕金森病（PD）与健康对照（HC）的比较中报告了不一致的结果。
我们在数据库（PubMed、Web of Science 和 Google Scholar）中搜索了截至 2021 年 12 月之前发表的研究。对 PD 患者的功能变化进行了激活似然估计（ALE）荟萃分析。
该研究最终纳入了 25 项研究（包括 973 例 PD 患者和 766 例 HC）。与 HC 相比，PD 患者左侧颞上回（STG）、左侧额上回（SFG）、左侧额内侧回（MFG）、左侧楔前叶（PCUN）和右侧豆状核的低频振幅（ALFF）降低。与 HC 相比，PD 患者右侧 SFG、左侧顶叶上回（SPL）、左侧 STG、右侧梭状回、左侧颞下回（ITG）和右侧海马旁回的 ALFF 增加。与 HC 相比，PD 患者右侧后扣带回（PCG）、右侧 MFG、左侧尖峰和左侧丘脑的局部一致性（ReHo）降低。与 HC 相比，PD 患者右侧 SFG 的 ReHo 增加。此外，与 HC 相比，PD 患者右侧后扣带回（PCG）的功能连接（FC）降低。
本 ALE 分析证实了 PD 患者在运动、情绪和认知相关区域的功能缺陷。rs-fMRI 研究中这些区域的缺陷可能在 PD 的早期诊断中发挥作用。
