Apor Emmanuel, O'Brien Jennifer, Stephen Merin, Castillo Jorge J
Department of Medicine, Rhode Island Hospital, Providence, RI, USA; Department of Medicine, The Miriam Hospital, Providence, RI, USA.
Division of Hematology and Oncology, Roger Williams Medical Center, Providence, RI, USA.
Leuk Res. 2014 Sep;38(9):1067-71. doi: 10.1016/j.leukres.2014.06.025. Epub 2014 Jul 10.
Our objective was to define the risk of lymphoma, leukemia and myeloma in adult patients with SLE with a meta-analysis of prospective cohort studies. A literature search from 1995 to 2013 revealed eight studies evaluating this association. The outcome of interest was the standardized incidence ratio (SIR). Our study included 401 cases in a cohort of approximately 68,000 SLE patients, and showed an increased incidence of all hematologic malignancies (SIR 2.9), non-Hodgkin lymphoma (SIR 5.7), Hodgkin lymphoma (SIR 3.1), leukemia (SIR 2.3) and myeloma (SIR 1.5) in SLE patients compared with the general population. The increased SIR was consistent regardless of age, sex or geographical region.
我们的目标是通过对前瞻性队列研究进行荟萃分析，确定成年系统性红斑狼疮（SLE）患者患淋巴瘤、白血病和骨髓瘤的风险。对1995年至2013年的文献检索发现了八项评估这种关联的研究。感兴趣的结果是标准化发病率（SIR）。我们的研究纳入了约68000名SLE患者队列中的401例病例，结果显示，与普通人群相比，SLE患者所有血液系统恶性肿瘤（SIR 2.9）、非霍奇金淋巴瘤（SIR 5.7）、霍奇金淋巴瘤（SIR 3.1）、白血病（SIR 2.3）和骨髓瘤（SIR 1.5）的发病率均有所增加。无论年龄、性别或地理区域如何，SIR升高都是一致的。
