Long Yubin, Pan Yujun, Yang Houzhi, Wang Xiangbin, Jiang Zichao, Sun Tianwei
Tianjin Medical University, Tianjin, China.
Department of Spinal Surgery, The Central Hospital of Shaoyang, Shaoyang, Hunan, China.
J Cancer. 2025 Jan 1;16(2):567-576. doi: 10.7150/jca.103693. eCollection 2025.
Whether autoimmune diseases caused any effects on the risk of cancers remained yet clarified. This study aimed to investigate the causal effect of autoimmune diseases on pan-cancers through mendelian randomization (MR) analysis. The GWAS summary datasets of 10 autoimmune diseases were derived from the IEU or UK biobank website. The GWAS summary datasets of 39 cancers were derived from the FinnGen website. The Inverse-Variance Weighted (IVW) method was used to analyze the causal association between auto-immune diseases and pan-cancers. MR analysis indicated that inflammatory bowel disease would significantly increase the risk of rectum cancer, basal cell carcinoma and skin cancer, while Crohn's disease only showed causal association with increased risk of skin cancer. Rheumatoid arthritis significantly increased the risk of thyroid gland cancer, while reduce the risk of overall cancers and 7 other types of cancer outcomes. Ankylosing spondylitis showed causal relationship with increased risk of overall cancers and 5 other types of cancer outcomes. Multiple sclerosis significantly increased the risk of overall cancers and 5 other types of cancer outcomes, while reduce the risk of pancreas cancer (P=0.04). Parkinson's disease significantly reduced the risk of rectum cancer and skin cancer. Systemic lupus erythematosus significantly increased the risk of 3 types of cancer, while reduced the risk of kidney and urinary tract cancer. Psoriasis significantly increased the risk of head neck and oral cavity cancer, while reduced the risk of 3 other types of cancer. This study provides novel genetic epidemiological evidence linking several autoimmune diseases to various cancer, both retrospective studies and basic research on this topic should carefully consider the genetic susceptibility to autoimmune diseases in relation to cancer, including potential risk and protective factors. These findings may inform preventive strategies and treatment approaches.
自身免疫性疾病是否对癌症风险产生任何影响仍未明确。本研究旨在通过孟德尔随机化（MR）分析探讨自身免疫性疾病对泛癌的因果效应。10种自身免疫性疾病的全基因组关联研究（GWAS）汇总数据集来自IEU或英国生物银行网站。39种癌症的GWAS汇总数据集来自芬兰基因研究（FinnGen）网站。采用逆方差加权（IVW）方法分析自身免疫性疾病与泛癌之间的因果关联。MR分析表明，炎症性肠病会显著增加直肠癌、基底细胞癌和皮肤癌的风险，而克罗恩病仅显示与皮肤癌风险增加存在因果关联。类风湿性关节炎显著增加甲状腺癌的风险，同时降低总体癌症及其他7种癌症结局的风险。强直性脊柱炎显示与总体癌症及其他5种癌症结局的风险增加存在因果关系。多发性硬化症显著增加总体癌症及其他5种癌症结局的风险，同时降低胰腺癌的风险（P = 0.04）。帕金森病显著降低直肠癌和皮肤癌的风险。系统性红斑狼疮显著增加3种癌症的风险，同时降低肾脏和泌尿系统癌症的风险。银屑病显著增加头颈和口腔癌的风险，同时降低其他3种癌症的风险。本研究提供了新的遗传流行病学证据，将几种自身免疫性疾病与各种癌症联系起来，关于这一主题的回顾性研究和基础研究均应仔细考虑自身免疫性疾病与癌症相关的遗传易感性，包括潜在的风险和保护因素。这些发现可能为预防策略和治疗方法提供参考。
