利用异源遗传转录模块快速构建通用分子逻辑门
Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules.
作者信息
Wang Baojun, Buck Martin
机构信息
Centre for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, UK.
出版信息
Chem Commun (Camb). 2014 Oct 11;50(79):11642-4. doi: 10.1039/c4cc05264a.
Abstract
We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices serve to achieve increased sensing signal selectivity.
摘要
我们在细菌细胞中设计并构建了通用模块化遗传逻辑门。这些逻辑门可作为数字逻辑的1输入缓冲门、具有一个反向输入的2输入和3输入与门，并以定制逻辑方式整合多个化学输入信号。这种快速设计的装置有助于提高传感信号的选择性。
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