与暴力相关的创伤后应激障碍以及在看到充满情感的男女互动时的神经激活。
Violence-related PTSD and neural activation when seeing emotionally charged male-female interactions.
作者信息
Moser Dominik A, Aue Tatjana, Suardi Francesca, Kutlikova Hana, Cordero Maria I, Rossignol Ana Sancho, Favez Nicolas, Rusconi Serpa Sandra, Schechter Daniel S
机构信息
Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland
Faculty of Psychology and Education, University of Geneva, Geneva, Switzerland, Child and Adolescent Psychiatry, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland, Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
出版信息
Soc Cogn Affect Neurosci. 2015 May;10(5):645-53. doi: 10.1093/scan/nsu099. Epub 2014 Jul 25.
Post-traumatic stress disorder (PTSD) is a disorder that involves impaired regulation of the fear response to traumatic reminders. This study tested how women with male-perpetrated interpersonal violence-related PTSD (IPV-PTSD) differed in their brain activation from healthy controls (HC) when exposed to scenes of male-female interaction of differing emotional content. Sixteen women with symptoms of IPV-PTSD and 19 HC participated in this study. During magnetic resonance imaging, participants watched a stimulus protocol of 23 different 20 s silent epochs of male-female interactions taken from feature films, which were neutral, menacing or prosocial. IPV-PTSD participants compared with HC showed (i) greater dorsomedial prefrontal cortex (dmPFC) and dorsolateral prefrontal cortex (dlPFC) activation in response to menacing vs prosocial scenes and (ii) greater anterior cingulate cortex (ACC), right hippocampus activation and lower ventromedial prefrontal cortex (vmPFC) activty in response to emotional vs neutral scenes. The fact that IPV-PTSD participants compared with HC showed lower activity of the ventral ACC during emotionally charged scenes regardless of the valence of the scenes suggests that impaired social perception among IPV-PTSD patients transcends menacing contexts and generalizes to a wider variety of emotionally charged male-female interactions.
创伤后应激障碍（PTSD）是一种涉及对创伤性提示物的恐惧反应调节受损的疾病。本研究测试了患有男性实施的人际暴力相关创伤后应激障碍（IPV-PTSD）的女性在接触不同情感内容的男女互动场景时，其大脑激活与健康对照组（HC）有何不同。16名有IPV-PTSD症状的女性和19名健康对照者参与了本研究。在磁共振成像过程中，参与者观看了一个刺激方案，该方案包含从故事片中选取的23个不同的20秒男女互动无声片段，这些片段分别为中性、威胁性或亲社会的。与健康对照组相比，IPV-PTSD参与者表现出：（i）在面对威胁性场景与亲社会场景时，背内侧前额叶皮质（dmPFC）和背外侧前额叶皮质（dlPFC）的激活更强；（ii）在面对情感性场景与中性场景时，前扣带回皮质（ACC）、右侧海马体的激活更强，而腹内侧前额叶皮质（vmPFC）的活动更低。与健康对照组相比，IPV-PTSD参与者在情绪激动的场景中，无论场景的效价如何，腹侧ACC的活动都较低，这一事实表明，IPV-PTSD患者的社会认知受损超越了威胁性情境，并扩展到更广泛的情绪激动的男女互动中。
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