Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No, 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040, China.
Eur J Med Res. 2014 Jul 25;19(1):40. doi: 10.1186/2047-783X-19-40.
The objective of this study was to systematically evaluate the contribution of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to type 2 diabetes mellitus (T2DM) and its interaction with obesity to T2DM susceptibility.
To clarify whether IGF2BP2 is an independent risk factor for T2DM in Chinese population, we conducted a study with a total of 2,301 Chinese Han subjects, including 1,166 T2DM patients and 1,135 controls, for the genotype of a most common and widely studied polymorphism-rs4402960 of IGF2BP2. Genotyping was performed by iPLEX technology. Gene and environment interaction analysis was performed by using multiple logistic regression models.
The repeatedly confirmed association between IGF2BP2 (rs4402960) and T2DM had not been replicated in this cohort (P = 0.182). Interestingly, we found that obese subjects (body mass index (BMI) ≥ 28.0 kg/m2) bearing the minor A allele had an increased risk to develop T2DM (P = 0.008 for allele analysis and P < 0.001 for genotype analysis).
The present study provided data suggesting that the wild C allele of IGF2BP2 (rs4402960) had a protective effect against T2DM in obese subjects of Chinese Han population.
本研究旨在系统评估胰岛素样生长因子 2 mRNA 结合蛋白 2（IGF2BP2）对 2 型糖尿病（T2DM）的贡献及其与肥胖对 T2DM 易感性的相互作用。
为了明确 IGF2BP2 是否是中国人群 T2DM 的独立危险因素，我们共纳入 2301 例中国汉族受试者，包括 1166 例 T2DM 患者和 1135 例对照，对最常见和广泛研究的 IGF2BP2 多态性 rs4402960 的基因型进行检测。基因分型采用 iPLEX 技术。采用多因素 logistic 回归模型进行基因-环境交互作用分析。
在该队列中，IGF2BP2（rs4402960）与 T2DM 之间的关联并未得到重复验证（P = 0.182）。有趣的是，我们发现肥胖受试者（BMI≥28.0 kg/m2）携带较小的 A 等位基因时，发生 T2DM 的风险增加（等位基因分析 P = 0.008，基因型分析 P < 0.001）。
本研究提供的数据表明，IGF2BP2（rs4402960）的野生 C 等位基因对中国汉族肥胖人群 T2DM 具有保护作用。
