IGF2BP2、HMG20A 和 HNF1B 基因多态性对中国汉族人群 2 型糖尿病易感性的影响。
Influence of IGF2BP2, HMG20A, and HNF1B genetic polymorphisms on the susceptibility to Type 2 diabetes mellitus in Chinese Han population.
机构信息
Nursing Department, The First Affiliated Hospital of Xi'an Jiaotong University. Xi'an 710061, China.
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
出版信息
Biosci Rep. 2020 May 29;40(5). doi: 10.1042/BSR20193955.
BACKGROUND
The present study aimed to investigate the roles of insulin related gene IGF2BP2, HMG20A, and HNF1B variants in the susceptibility of Type 2 diabetes mellitus (T2DM), and to identify their association with age, gender, BMI, and smoking and alcohol drinking behavior among the Han Chinese population.
METHODS
About 508 patients with T2DM and 503 healthy controls were enrolled. Rs11927381 and rs7640539 in IGF2BP2, rs7178572 in HMG20A, rs4430796, and rs11651052 in HNF1B were genotyped by using the Agena MassARRAY. Odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression.
RESULTS
We found that HMG20A rs7178572 (OR = 1.25, P = 0.015) and HNF1B rs11651052 (OR = 1.26, P = 0.019) increased the risk of T2DM. Rs7178572, rs4430796, and rs11651052 might be related to the higher T2DM susceptibility not only by itself but also by interacting with age, gender smoking, and alcohol drinking. Rs11927381 also conferred the higher T2DM susceptibility at age ≤ 59 years. Besides, rs7178572-AA (P = 0.032) genotype and rs11651052 GG (P = 0.018) genotype were related to higher glycated hemoglobin and insulin level, respectively.
CONCLUSION
Specifically, we first found that rs11927381, rs7640539, and rs11651052 were associated with risk of T2DM among the Han Chinese population. We also provide evidence that age, gender, BMI, smoking, and drinking status have an interactive effect with these variants on T2DM susceptibility.
背景
本研究旨在探讨胰岛素相关基因 IGF2BP2、HMG20A 和 HNF1B 变异与 2 型糖尿病（T2DM）易感性的关系，并鉴定它们与汉族人群中年龄、性别、BMI、吸烟和饮酒行为的相关性。
方法
纳入了约 508 例 T2DM 患者和 503 例健康对照者。采用 Agena MassARRAY 方法检测 IGF2BP2 中的 rs11927381 和 rs7640539、HMG20A 中的 rs7178572、HNF1B 中的 rs4430796 和 rs11651052 基因型。采用 logistic 回归计算比值比（OR）及其 95%置信区间（CI）。
结果
我们发现 HMG20A rs7178572（OR=1.25，P=0.015）和 HNF1B rs11651052（OR=1.26，P=0.019）增加了 T2DM 的发病风险。rs7178572、rs4430796 和 rs11651052 不仅单独，而且与年龄、性别、吸烟和饮酒等因素相互作用，可能与更高的 T2DM 易感性有关。rs11927381 还与≤59 岁人群中更高的 T2DM 易感性有关。此外，rs7178572-AA 基因型（P=0.032）和 rs11651052-GG 基因型（P=0.018）与更高的糖化血红蛋白和胰岛素水平有关。
结论
本研究首次发现 rs11927381、rs7640539 和 rs11651052 与汉族人群 T2DM 发病风险相关。我们还提供了证据表明，年龄、性别、BMI、吸烟和饮酒状况与这些变异体在 T2DM 易感性上存在交互作用。
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