Khokha R, Wolfe B M
Atherosclerosis. 1984 Sep;52(3):329-38. doi: 10.1016/0021-9150(84)90063-7.
The progestin, levonorgestrel administered orally to fed female rats significantly lowers both plasma total and very low density lipoprotein triglycerides. In contrast, plasma total cholesterol and low density lipoprotein cholesterol rose significantly. Suspensions of isolated hepatocytes were used to study the effects of levonorgestrel on triglyceride synthesis by examining the incorporation of labelled precursors [( 9,10- 3H]palmitate and [U-14C]glycerol) into triglycerides. Levonorgestrel (10(-4) M) significantly inhibited the incorporation of both precursors into hepatocyte triglycerides and also reduced their incorporation into the triglycerides (nearly all in d less than 1.006) released into the medium. These results suggest that inhibition of hepatic triglyceride synthesis and release can account at least for part of the lowering of plasma VLDL which occurs during administration of levonorgestrel.
给进食后的雌性大鼠口服孕激素左炔诺孕酮，可显著降低血浆总甘油三酯和极低密度脂蛋白甘油三酯水平。相比之下，血浆总胆固醇和低密度脂蛋白胆固醇则显著升高。利用分离的肝细胞悬液，通过检测标记前体物[（9,10-³H]棕榈酸酯和[U-¹⁴C]甘油）掺入甘油三酯的情况，研究左炔诺孕酮对甘油三酯合成的影响。左炔诺孕酮（10⁻⁴M）显著抑制两种前体物掺入肝细胞甘油三酯，同时也减少其掺入释放到培养基中的甘油三酯（几乎所有d均小于1.006）。这些结果表明，抑制肝脏甘油三酯的合成与释放至少可以部分解释左炔诺孕酮给药期间血浆极低密度脂蛋白水平降低的原因。
