职业压力与亚临床动脉粥样硬化：一项系统综述
Occupational stress and subclinical atherosclerosis: a systematic review.
作者信息
Wilson Mark D, Conroy Lorraine M, Dorevitch Samuel
出版信息
Int J Occup Environ Health. 2014 Oct;20(4):271-80. doi: 10.1179/2049396714Y.0000000076. Epub 2014 Jul 29.
BACKGROUND
Stress is a common hazard in the work environment and is associated with multiple adverse health effects. The association between work-related stress (WRS) and cardiovascular disease has been established in a number of epidemiological studies.
METHODS
A systematic review was conducted according to the PRISMA statement of the English literature involving WRS and carotid artery intima media thickness (CIMT).
RESULTS
Four cohorts and six cross-sectional studies of occupational stress and CIMT were identified. All cohorts and five of the cross-sectional studies reported a significant positive association, while one reported an inverse association of WRS and CIMT.
DISCUSSION
The weight of the evidence that we were able to identify suggests that occupational stress results in an increased risk of atherosclerosis, assessed via CIMT. Studies that include longitudinal measures of stress and intermediate cardiac endpoints, with adequate accounting for confounders, are needed. Interventional studies should also be conducted to determine whether CIMT progression can be prevented with workplace stress reduction.
背景
压力是工作环境中常见的危害因素，与多种不良健康影响相关。工作相关压力（WRS）与心血管疾病之间的关联已在多项流行病学研究中得到证实。
方法
根据PRISMA声明，对涉及WRS和颈动脉内膜中层厚度（CIMT）的英文文献进行系统综述。
结果
确定了四项关于职业压力与CIMT的队列研究和六项横断面研究。所有队列研究和五项横断面研究均报告了显著的正相关，而一项研究报告了WRS与CIMT的负相关。
讨论
我们能够确定的证据表明，职业压力会导致通过CIMT评估的动脉粥样硬化风险增加。需要开展包括压力纵向测量和心脏中间终点，并充分考虑混杂因素的研究。还应进行干预性研究，以确定减轻工作场所压力是否可以预防CIMT进展。
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