Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris F-75015, France; INSERM U604, Paris F-75015, France; and INRA, USC2020, Paris F-75015, France.
Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8):a016972. doi: 10.1101/cshperspect.a016972.
Of the many pathogens that infect humans and animals, a large number use cells of the host organism as protected sites for replication. To reach the relevant intracellular compartments, they take advantage of the endocytosis machinery and exploit the network of endocytic organelles for penetration into the cytosol or as sites of replication. In this review, we discuss the endocytic entry processes used by viruses and bacteria and compare the strategies used by these dissimilar classes of pathogens.
在感染人类和动物的众多病原体中,有很大一部分利用宿主细胞作为复制的保护场所。为了到达相关的细胞内隔室,它们利用内吞作用机制,并利用内吞细胞器网络穿透细胞质或作为复制部位。在这篇综述中,我们讨论了病毒和细菌使用的内吞进入过程,并比较了这些不同类病原体使用的策略。